Evidence map›Paper›PMID 33390901›Full record

ArticleFrontiers in molecular neuroscience2020

Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome.

Sally Spendiff, Rachel Howarth, Grace McMacken, Tracey Davey, Kaitlyn Quinlan, Emily O'Connor, Clarke Slater, Stefan Hettwer, Armin Mäder, Andreas Roos and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Building, Breaking, and Repairing Neuromuscular Synapses.Cold Spring Harbor perspectives in biology · 2024
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Sally SpendiffChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Rachel HowarthInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
Grace McMackenDepartment of Neurosciences, Royal Victoria Hospital, Belfast, United Kingdom.
Tracey DaveyInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
Kaitlyn QuinlanChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Emily O'ConnorChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Clarke SlaterInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
Stefan HettwerNeurotune AG, Schlieren, Zurich.
Armin MäderNeurotune AG, Schlieren, Zurich.
Andreas RoosChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Rita HorvathDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
Hanns LochmüllerChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Children's Hospital of Eastern Ontario · CANewcastle University · GBNeurotune (Switzerland) · CHRoyal Victoria Hospital · GBUniversity of Cambridge · GBUniversity of Ottawa · CA

Funding

Medical Research Council G1000848Medical Research Council MR/N010035/1Medical Research Council MR/N025431/1Medical Research Council MR/N025431/2Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

animal modelcongenital myasthenia syndromes (CMS)neuromuscular disease (NMD)neuromuscular disordersneuromuscular junctionpreclinical “in vivo” studytherapies

Identifiers

PMID33390901
PMCPMC7773664
OpenAlexW3111282866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.