ReviewFrontiers in neuroscience2020
The Promise of Automated Home-Cage Monitoring in Improving Translational Utility of Psychiatric Research in Rodents.
Review in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Environmental enrichment: a systematic review on the effect of a changing spatial complexity on hippocampal neurogenesis and plasticity in rodents, with considerations for translation to urban and built environments for humans.Frontiers in neuroscience · 2024Pooled it
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Refining drug screening with automated home cage monitoring: a crossover study in socially housed rats.Frontiers in toxicology · 2026Article
- From pathology to network failure: a Question-Model-Outcome framework for interpreting animal models of AD-related and dementia-relevant mechanisms.Frontiers in aging neuroscience · 2026Review
- Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity.eNeuro · 2025Article
- Smart Lids for deep multi-animal phenotyping in standard home cages.Frontiers in behavioral neuroscience · 2025Article
- Robotic animals as new tools in rodent neuroscience research: proposed applications of zooinspired robots for mouse behavioral testing.Frontiers in behavioral neuroscience · 2025Article
- Article
- Behavioral characterization of triple-hit schizophrenia-like Lisket rats derived from the Long Evans strain through acute and chronic behavioral tests.Frontiers in psychiatry · 2025Article
- Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion.Physiological reports · 2024Article
- Rodent tests of depression and anxiety: Construct validity and translational relevance.Cognitive, affective & behavioral neuroscience · 2024Review
- ReptiLearn: An automated home cage system for behavioral experiments in reptiles without human intervention.PLoS biology · 2024Article
- The first rodent behavioral study (1822) and the diffusion of human-bred albino rats and mice in the 19th century.Frontiers in psychology · 2024Review
- Editorial: Animal-friendly methods for rodent behavioral testing in neuroscience research.Frontiers in behavioral neuroscience · 2024Article
- Article
- A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.Cell reports methods · 2023Article
- Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.Addiction neuroscience · 2023Article
- Article
- Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease.Frontiers in behavioral neuroscience · 2023Article
- IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system.Frontiers in behavioral neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Large number of promising preclinical psychiatric studies in rodents later fail in clinical trials, raising concerns about the efficacy of this approach to generate novel pharmacological interventions. In this mini-review we argue that over-reliance on behavioral tests that are brief and highly sensitive to external factors play a critical role in this failure and propose that automated home-cage monitoring offers several advantages that will increase the translational utility of preclinical psychiatric research in rodents. We describe three of the most commonly used approaches for automated home cage monitoring in rodents [e.g., operant wall systems (OWS), computerized visual systems (CVS), and automatic motion sensors (AMS)] and review several commercially available systems that integrate the different approaches. Specific examples that demonstrate the advantages of automated home-cage monitoring over traditional tests of anxiety, depression, cognition, and addiction-like behaviors are highlighted. We conclude with recommendations on how to further expand this promising line of preclinical research.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.