Evidence map›Paper›PMID 33390657›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2021

Changes in mRNA of immune factors expressed by milk somatic cells of Holstein cows with hypocalcemia after calving.

Hiromichi Ohtsuka, Misa Ohsawa, Kenji Murakami, Ryo Murata, Toshihide Kato, Motoshi Tajima

Open access · greenAbstract read
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. mRNA expression of immune factors by milk somatic cells from healthy Holstein lactating cows.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hiromichi OhtsukaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Misa OhsawaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Kenji MurakamiSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Ryo MurataSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Toshihide KatoSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Motoshi TajimaSchool of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan (Ohtsuka, Ohsawa, Murata, Kato, Tajima); Federation of Agricultural Mutual Relief Association, Fukagawa, Hokkaido 073-0022, Japan (Murakami).
Rakuno Gakuen University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in immune factors expressed by milk somatic cells from Holstein cows with hypocalcemia after calving were investigated in this study. Fourteen multiparous Holstein cows after their 3rd or 4th calving in one farm were used. The cows were divided into 2 groups: 7 cows needing treatment due to onset of hypocalcemia (hypocalcemia group; age = 5.53 ± 0.27 years, parity = 3.14 ± 0.14) and 7 cows without health problems (control group; age = 5.88 ± 0.31 years, parity = 3.57 ± 0.26). Milk samples were collected aseptically using a cannula and mRNA of immune factors expressed by milk somatic cells were analyzed. Milk samples (50 mL) were collected from the right rear mammary gland of cows before milking at day 1 and weeks 1, 2, 4, and 8 after calving. All milk samples showed a negative reaction to the California Mastitis Test. Levels of relative interleukin (IL)-6 and cathelicidin in the hypocalcemia group were lower than those in the control group in weeks 1 to 8. A significant difference in relative IL-6 levels was found in week 4 (

Indexed as

AnimalsCattleCattle DiseasesFemaleGene Expression RegulationHypocalcemiaImmunologic FactorsMilkPostpartum PeriodRNA, MessengerImmunologic FactorsRNA, Messenger

Identifiers

PMID33390657
PMCPMC7747659
OpenAlexW3120970643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.