Evidence map›Paper›PMID 33390521›Full record

ArticleChemical & pharmaceutical bulletin2021

Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge.

Unwoo Kang, Dongdong Wang, Heidi R Bokesch, Kirk R Gustafson

Abstract read
In one paragraph

Article in Chemical & pharmaceutical bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Unwoo KangMolecular Targets Program, Center for Cancer Research, National Cancer Institute.
Dongdong WangMolecular Targets Program, Center for Cancer Research, National Cancer Institute.
Heidi R BokeschMolecular Targets Program, Center for Cancer Research, National Cancer Institute.
Kirk R GustafsonMolecular Targets Program, Center for Cancer Research, National Cancer Institute.

Funding

Natural Products Discovery and Characterization Through Network CollaborationsZIABC011568 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DU, LIN · 2014 to 2025
$17.2M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011568NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Four new pregnane steroids, 3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16β-acetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (2), 12β-acetoxy-3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (3), and 12β,16β-diacetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (4) were isolated from an extract of an Epipolasis sp. marine sponge. The structures of the new compounds were determined by extensive NMR spectroscopic analysis and comparison with data from previously reported compounds.

Indexed as

AnimalsLactonesMagnetic Resonance SpectroscopyMolecular ConformationPoriferaPregnanesStereoisomerismLactonesPregnanescarbolactoneEpipolasismarine spongepregnane steroidstructure elucidation

Identifiers

PMID33390521
PMCPMC9341129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.