Evidence map›Paper›PMID 33390189›Full record

ArticlePilot and feasibility studies2021

A randomised controlled trial of energetic activity for depression in young people (READY): a multi-site feasibility trial protocol.

N Howlett, L Bottoms, A Chater, A B Clark, T Clarke, L David, K Irvine, A Jones, J Jones, S E Mengoni and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pilot and feasibility studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

N HowlettDepartment of Psychology, Sport, and Geography, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK. n.howlett@herts.ac.uk.ORCID http://orcid.org/0000-0002-6502-9969
L BottomsDepartment of Psychology, Sport, and Geography, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
A ChaterInstitute for Sport and Physical Activity Research (ISPAR), School of Sport Science and Physical Activity, Faculty of Health, Education, Sport and Social Science, University of Bedfordshire, Polhill Avenue, Bedford, MK41 9EA, UK.
A B ClarkNorwich Clinical Trials Unit, University of East Anglia, Norwich, Norfolk, NR4 7TR, UK.
T ClarkeNorfolk and Suffolk NHS Foundation Trust, Hellesdon Hospital, Drayton High Road, Norwich, NR6 5BE, UK.
L DavidCentre for Health Services and Clinical Research, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
K IrvineDepartment of Psychology, Sport, and Geography, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
A JonesNorwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.
J JonesCentre for Research in Public Health and Community Care, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
S E MengoniDepartment of Psychology, Sport, and Geography, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
J MurdochNorwich Clinical Trials Unit, University of East Anglia, Norwich, Norfolk, NR4 7TR, UK.
M PondNorwich Clinical Trials Unit, University of East Anglia, Norwich, Norfolk, NR4 7TR, UK.
S SharmaDepartment of Psychology, Sport, and Geography, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
E J SimsNorwich Clinical Trials Unit, University of East Anglia, Norwich, Norfolk, NR4 7TR, UK.
D A TurnerNorwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.
D WellstedCentre for Health Services and Clinical Research, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
J WilsonNorfolk and Suffolk NHS Foundation Trust, Hellesdon Hospital, Drayton High Road, Norwich, NR6 5BE, UK.
S WyattCentre for Health Services and Clinical Research, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
D TrivediCentre for Research in Public Health and Community Care, University of Hertfordshire, College Lane, Hatfield, Herts, AL10 9AB, UK.
University of East Anglia · GBUniversity of Hertfordshire · GBUniversity of Bedfordshire · GB

Funding

Health Technology Assessment Programme 17/78/10
6 · The paper itself

Abstract

backgroundPrevalence of depression is increasing in young people, and there is a need to develop and evaluate behavioural interventions which may provide benefits equal to or greater than talking therapies or pharmacological alternatives. Exercise could be beneficial for young people living with depression, but robust, large-scale trials of effectiveness and the impact of exercise intensity are lacking. This study aims to test whether a randomised controlled trial (RCT) of an intervention targeting young people living with depression is feasible by determining whether it is possible to recruit and retain young people, develop and deliver the intervention as planned, and evaluate training and delivery.

methodsThe design is a three-arm cluster randomised controlled feasibility trial with embedded process evaluation. Participants will be help-seeking young people, aged 13-17 years experiencing mild to moderate low mood or depression, referred from three counties in England. The intervention will be delivered by registered exercise professionals, supported by mental health support workers, twice a week for 12 weeks. The three arms will be high-intensity exercise, low-intensity exercise, and a social activity control. All arms will receive a 'healthy living' behaviour change session prior to each exercise session and the two exercise groups are energy matched. The outcomes are referral, recruitment, and retention rates; attendance at exercise sessions; adherence to and ability to reach intensity during exercise sessions; proportions of missing data; adverse events, all measured at baseline, 3, and 6 months; resource use; and reach and representativeness. DISCUSSION: UK National Health Service (NHS) policy is to provide young people with advice about using exercise to help depression but there is no evidence-based exercise intervention to either complement or as an alternative to medication or talking therapies. UK National Institute for Health and Care Excellence (NICE) guidelines suggest that exercise can be an effective treatment, but the evidence base is relatively weak. This feasibility trial will provide evidence about whether it is feasible to recruit and retain young people to a full RCT to assess the effectiveness and cost-effectiveness of an exercise intervention for depression.

trial registrationISRCTN, ISRCTN66452702 . Registered 9 April 2020.

Indexed as

Behaviour changeDepressionExerciseFeasibility trialLow moodPhysical activityYoung people

Identifiers

PMID33390189
PMCPMC7779325
OpenAlexW3120412632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.