ArticleJournal of neurodevelopmental disorders2021
Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder.
Article in Journal of neurodevelopmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Sensory Reactivity in Autism: Integrating Behavioural, Affective, Physiological, and Neural Dimensions.Current psychiatry reports · 2026Review
- Altered spectral patterns of aperiodic electroencephalography in autism.Psychiatry and clinical neurosciences · 2026Article
- Sensory processing, social-emotional development and adaptive behavior in preterm and full-term infants.BMC pediatrics · 2026Article
- A cascading effects model of early sensory development in autism.Psychological review · 2026Review
- Reward processing differences in autism: current understandings and future directions.Social cognitive and affective neuroscience · 2026Review
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
- Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Cortical markers of excitation/inhibition balance are associated with sensory responsivity from infancy in longitudinal cohorts enriched for autism and ADHD.Translational psychiatry · 2025Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Are prediction error modifications domain specific in autism but domain general in ADHD?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered tactile abnormalities in children with ASD during tactile processing and recognition revealed by dynamic EEG features.Frontiers in psychiatry · 2025Article
- Autism Spectrum Disorder in Children: Early Signs and Therapeutic Interventions.Children (Basel, Switzerland) · 2024Review
- Aggregated Pattern Classification Method for improving neural disorder stage detection.Brain and behavior · 2024Article
- "Neural Noise" in Auditory Responses in Young Autistic and Neurotypical Children.Journal of autism and developmental disorders · 2024Article
- Measuring habituation to stimuli: The Italian version of the Sensory Habituation Questionnaire.PloS one · 2024Article
- A Developmental Social Neuroscience Perspective on Infant Autism Interventions.Annual review of developmental psychology · 2023Article
- Habituation of auditory responses in young autistic and neurotypical children.Autism research : official journal of the International Society for Autism Research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundsAtypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits.
methodsNinety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively.
resultsThere was no effect of infants' likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits.
conclusionsReduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.