Evidence map›Paper›PMID 33390146›Full record

ReviewCurrent cardiology reviews2021

Analysis of Heart Rate Variability and Implication of Different Factors on Heart Rate Variability.

Reena Tiwari, Ravindra Kumar, Sujata Malik, Tilak Raj, Punit Kumar

8 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Current cardiology reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 231 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
231citing papers in PubMed, 13 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06429423 nacompletednot on this mapstarted 2023, after this paper: background citation

Acute Psychological and Physiological Exercise Effects Among Patients With Stress-related Exhaustion Disorder. Role of Exercise Intensity.

TypeinterventionalSponsorVictoria BlomRan2023 to 2024Enrolled60ConditionsExhaustion, SyndromeArmsAcute exercise low intensity, Acute exercise moderate intensity
NCT07097168 withdrawnnot on this mapstarted 2025, after this paper: background citation

Evaluating Clinical Course in Coronary Artery Bypass Patients Using the WHOOP Fitness Band Heart Rate Variability Application.

TypeobservationalSponsorTufts Medical CenterRan2025 to 2026Enrolled0ConditionsCoronary Artery Disease
NCT07356635 narecruitingnot on this mapstarted 2025, after this paper: background citation

Investigating Cardiovascular Reactivity and Recovery of Young Adults During Grief-Recall, With Self-Affirmation as Potential Intervention

TypeinterventionalSponsorUniversity of South FloridaRan2025 to 2027Enrolled140ConditionsGrief, Cardiovascular Health, EmotionArmsValue-affirmation
NCT07407829 narecruitingnot on this mapstarted 2025, after this paper: background citation

Step by Step Back - A Feasibility Study of a CBT-Based Physical Activity Intervention for Stress-Related Exhaustion

TypeinterventionalSponsorThe Swedish School of Sport and Health SciencesRan2025 to 2026Enrolled20ConditionsExhaustion Disorder, Stress-Related DisordersArmsCBT/ACT-based psychologist-delivered physical activity program
NCT07443072 recruitingnot on this mapstarted 2026, after this paper: background citation

Heart Rate Variability and Processed EEG Features as Predictors of Postoperative Outcomes After Cranial Neurosurgery - A Prospective Observational Study in the Post-Anesthesia Care Unit

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2026 to 2027Enrolled300ConditionsCranial Neurosurgery
NCT07591935 nacompletednot on this mapstarted 2024, after this paper: background citation

Artificial Intelligence and Mindfulness Meditation: Innovative Methods to Reduce Stress Amongst Medical School Students

TypeinterventionalSponsorSaint James School of MedicineRan2024 to 2024Enrolled20ConditionsStressArmsMindfulness-Based Stress Reduction Course, Apollo Neuro Wearable
NCT07620249 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effects of Combined Thoracic Expansion Exercises and Slow Diaphragmatic Breathing on Cognitive Function, Brain Activation, Psychological Status, and Head-Shoulder Posture in Healthy Adults

TypeinterventionalSponsorNational Taiwan University Clinical Trial CenterRan2026 to 2027Enrolled60ConditionsDiaphragm PacingArmsthoracic expansion exercises and slow diaphragmatic breathing, Sham Block
NCT07670806 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of an Osteopathic Intervention Protocol on the Parasympathetic System on Stress and Anxiety in Young Adults: a Randomized Clinical Trial

TypeinterventionalSponsorEscola Superior de Tecnologia da Saúde do PortoRan2026 to 2026Enrolled30ConditionsStress, AnxietyArmsFourth Ventricle Technique, Suboccipital Decompression, Diaphragm Myofascial Release Technique, Sacral Rock, Sham Cranial Listening
3 · Its place in the literature

Who cites it

231 citing papers in PubMed, 13 syntheses or guidelines pooled it, 416 citations in OpenAlex.

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171 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Reena TiwariDepartment of Morphology and Physiology, Karaganda Medical University, Karaganda 100008, Kazakhstan.
Ravindra KumarDepartment of Pathology, Karaganda Medical University, Karaganda 100008, Kazakhstan.
Sujata MalikDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kalyanpur, Kanpur, Uttar Pradesh-208016, India.
Tilak RajDepartment of Zoology, Pt. Neki Ram Sharma Government College, Rohtak, Haryana 124001, India.
Punit KumarDepartment of Biomedicine, Karaganda Medical University, Karaganda 100008, Kazakhstan.
Karaganda Medical University · KZGovernment of Haryana · INIndian Institute of Technology Kanpur · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe heart is the central organ of the circulatory system, which maintains the flow of blood along with the transport of nutrients to different cells and tissues. A well-functioning cardiac state is a complicated mode of changeability. A healthy heart is not only about oscillation, as the rhythmometer is not the same in every circumstance. Heart rate shows variations so that it can be regulated according to psychophysiological conditions to maintain the effect of the internal-external stimulus.

objectiveThe main objective of this review is to provide a piece of all-inclusive information about heart rate variability (HRV) and different variables affecting HRV. The direct interconnection so that HRV can be used in clinical practices.

methodsThis review article contains a detailed survey of literature about HRV available in different online sources such as; Google Scholar, Science Direct, PubMed, and Web of Science, etc. In this review, the authors have focused on the role of the autonomic nervous system in the regulation of HRV and the role of various factors affecting HRV.

resultsThe variation in the time between two heartbeats is termed as HRV. It is one of the indicators of many pathological conditions related to cardiovascular health. It provided reliable information about the interaction of the sympathetic and parasympathetic nervous systems. The analysis of the variation of heart rate is a well-known non-invasive technique to identify the functioning of the autonomic nervous system. The autonomic nervous system (ANS) depends on the sympathetic and parasympathetic nervous system for transferring information. The cardio-accelerating center, lungs, and non-striated muscles are innervated by cardiac sympathetic nerves. This division of ANS latches upon the heart accordingly via the cervicothoracic ganglion and vagus nerve. It is found that cardiac normal variability depends upon this stimulation towards the sinoatrial node (pacemaker), which can be evaluated by analyzing the HRV. In human-based studies, it has been found that a low level of HRV is one of the main causes of death rate among adults. Hence, HRV helps in identifying the risk of cardiac diseases and the state of ANS.

conclusionThe heart plays a vital role in the human body and the well-functioning of the cardiac system is the need for a healthy life. The heart contains its nervous system termed as neurocardio system in which ANS plays a key role in which the sympathetic and parasympathetic systems interplay to regulate HRV. High HRV is associated with healthy condition, while low HRV is associated with pathological conditions. The HRV is influenced by various variables such as; pathological, physiological, psychological, environmental factors, lifestyle factors, and genetic factors, etc.

Indexed as

Autonomic Nervous SystemHeartHeart RateHumansautonomic nervous systembrain-heart connectioncardiac ganglia: Heartheart rate variabilityparasympathetic nervous systems.sympathetic nervous systems

Identifiers

PMID33390146
PMCPMC8950456
OpenAlexW3120791867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.