Evidence map›Paper›PMID 33390053›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Intrinsic Frequencies of Carotid Pressure Waveforms Predict Heart Failure Events: The Framingham Heart Study.

Leroy L Cooper, Jian Rong, Niema M Pahlevan, Derek G Rinderknecht, Emelia J Benjamin, Naomi M Hamburg, Ramachandran S Vasan, Martin G Larson, Morteza Gharib, Gary F Mitchell

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Observational
  2. Assessment of Myocardial Injury Size Metrics Using Carotid Pressure Waveform: Proof-of-Concept in Coronary Occlusion/Reperfusion Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  3. Article
  4. A spectral machine learning approach to derive central aortic pressure waveforms from a brachial cuff.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Leroy L CooperFrom the Biology Department, Vassar College, Poughkeepsie, NY (L.L.C.).
Jian RongBoston University and NHLBI's Framingham Heart Study, MA (J.R., E.J.B., R.S.V., M.G.L.).
Niema M PahlevanDepartment of Aerospace and Mechanical Engineering (N.M.P.), University of Southern California, Los Angeles.
Derek G RinderknechtGraduate Aerospace Laboratories, Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena (D.G.R., M.G.).
Emelia J BenjaminBoston University and NHLBI's Framingham Heart Study, MA (J.R., E.J.B., R.S.V., M.G.L.).
Naomi M HamburgEvans Department of Medicine (E.J.B., N.M.H., R.S.V.), Boston University School of Medicine, MA.
Ramachandran S VasanBoston University and NHLBI's Framingham Heart Study, MA (J.R., E.J.B., R.S.V., M.G.L.).
Martin G LarsonBoston University and NHLBI's Framingham Heart Study, MA (J.R., E.J.B., R.S.V., M.G.L.).
Morteza GharibGraduate Aerospace Laboratories, Division of Engineering and Applied Sciences, California Institute of Technology, Pasadena (D.G.R., M.G.).
Gary F MitchellCardiovascular Engineering, Inc, Norwood, MA (G.F.M.).
Boston University · USCalifornia Institute of Technology · USNorwood Hospital · USUniversity of Southern California · USVassar College · US

Funding

THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01HC25195
6 · The paper itself

Abstract

Intrinsic frequencies (IFs) derived from arterial waveforms are associated with cardiovascular performance, aging, and prevalent cardiovascular disease (CVD). However, prognostic value of these novel measures is unknown. We hypothesized that IFs are associated with incident CVD risk. Our sample was drawn from the Framingham Heart Study Original, Offspring, and Third Generation Cohorts and included participants free of CVD at baseline (N=4700; mean age 52 years, 55% women). We extracted 2 dominant frequencies directly from a series of carotid pressure waves: the IF of the coupled heart and vascular system during systole (ω

Indexed as

AdultAgedBlood PressureCarotid ArteriesFemaleHeartHeart FailureHemodynamicsHumansIncidenceLongitudinal StudiesMaleMiddle AgedPrognosisRiskRisk Assessmentblood pressurecardiovascular diseasesepidemiologyheart failureprognosis

Identifiers

PMID33390053
PMCPMC7803452
OpenAlexW3118363791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.