ArticleHypertension (Dallas, Tex. : 1979)2021
Genetically Predicted Blood Pressure and Risk of Atrial Fibrillation.
Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Guideline
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Impact of Blood Pressure in the Early 40s on Left Atrial Volumes in the Mid-60s: Data From the ACE 1950 Study.Journal of the American Heart Association · 2022Trial
- Atrial fibrillation development in the heart failure population from nationwide British linked electronic health records.ESC heart failure · 2025Article
- Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization.JACC. Asia · 2025Article
- EXPRESSION OF CONNEXIN-40 AND INTERLEUKIN 6 GENES IN PATIENTS WITH ATRIAL FIBRILLATION.Acta clinica Croatica · 2025Article
- Combining genetic proxies of drug targets and time-to-event analyses from longitudinal observational data to identify target patient populations.BMC cardiovascular disorders · 2025 · on this mapObservational
- Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults.Nature communications · 2024Article
- Type 2 Diabetes and Atrial Fibrillation: Evaluating Causal and Pleiotropic Pathways Using Mendelian Randomization.Journal of the American Heart Association · 2023Article
- Epidemiology and modifiable risk factors for atrial fibrillation.Nature reviews. Cardiology · 2023Review
- Inflammatory bowel disease is causally related to irritable bowel syndrome: a bidirectional two-sample Mendelian randomization study.Frontiers in medicine · 2023Article
- Unravelling the Distinct Effects of Systolic and Diastolic Blood Pressure Using Mendelian Randomisation.Genes · 2022Article
- Arterial stiffness and atrial fibrillation: A review.Clinics (Sao Paulo, Brazil) · 2022Review
- Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization.Translational andrology and urology · 2021Article
- Discovery and implications of polygenicity of common diseases.Science (New York, N.Y.) · 2021Review
- Hypertension and Atrial Fibrillation: A Study on Epidemiology and Mendelian Randomization Causality.Frontiers in cardiovascular medicine · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Observational studies have shown an association between hypertension and atrial fibrillation (AF). Aggressive blood pressure management in patients with known AF reduces overall arrhythmia burden, but it remains unclear whether hypertension is causative for AF. To address this question, this study explored the relationship between genetic predictors of blood pressure and risk of AF. We secondarily explored the relationship between genetically proxied use of antihypertensive drugs and risk of AF. Two-sample Mendelian randomization was performed using an inverse-variance weighted meta-analysis with weighted median Mendelian randomization and Egger intercept tests performed as sensitivity analyses. Summary statistics for systolic blood pressure, diastolic blood pressure, and pulse pressure were obtained from the International Consortium of Blood Pressure and the UK Biobank discovery analysis and AF from the 2018 Atrial Fibrillation Genetics Consortium multiethnic genome-wide association studies. Increases in genetically proxied systolic blood pressure, diastolic blood pressure, or pulse pressure by 10 mm Hg were associated with increased odds of AF (systolic blood pressure: odds ratio [OR], 1.17 [95% CI, 1.11-1.22];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.