Evidence map›Paper›PMID 33389779›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2021

StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.

Angela M Noecker, Anneke M Frankemolle-Gilbert, Bryan Howell, Mikkel V Petersen, Sinem Balta Beylergil, Aasef G Shaikh, Cameron C McIntyre

Open access · greenAbstract read
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Prospective Connectomic-Based Deep Brain Stimulation Programming for Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  10. Article
  11. Article
  12. Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angela M NoeckerDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Anneke M Frankemolle-GilbertDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0003-0724-8087
Bryan HowellDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-3329-8478
Mikkel V PetersenDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Sinem Balta BeylergilDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Aasef G ShaikhDepartment of Neurology, Case Western Reserve University, Cleveland, OH, USA.
Cameron C McIntyreDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0003-0932-854X
Case Western Reserve University · US

Funding

Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
Pathway targeted deep brain stimulation for Parkinson's diseaseR01NS085188 · NINDS · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM, MCINTYRE, CAMERON · 2013 to 2017
$3.4M
Augmented Reality Platform for Deep Brain StimulationR01NS105690 · NINDS · DUKE UNIVERSITY · PI MCINTYRE, CAMERON · 2018 to 2022
$2.2M
Subthalamic deep brain stimulation to modulate vestibular heading perception in Parkinson’s disease.I01CX002086 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI SHAIKH, AASEF G · 2021 to 2024
–
CSRD VA I01 CX002086NINDS NIH HHS P50 NS098573NINDS NIH HHS R01 NS085188NINDS NIH HHS R01 NS105690
6 · The paper itself

Abstract

objectiveSubthalamic deep brain stimulation (DBS) is an established therapy for Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated by DBS. This article describes our approach and methods for evolving the StimVision software platform to meet the technical demands of connectomic DBS modeling in the subthalamic region. MATERIALS AND

methodsStimVision v2 was developed with Visualization Toolkit (VTK) libraries and integrates four major components: 1) medical image visualization, 2) axonal pathway visualization, 3) electrode positioning, and 4) stimulation calculation.

resultsStimVision v2 implemented two key technological advances for connectomic DBS analyses in the subthalamic region. First was the application of anatomical axonal pathway models to patient-specific DBS models. Second was the application of a novel driving-force method to estimate the response of those axonal pathways to DBS. Example simulations with directional DBS electrodes and clinically defined therapeutic DBS settings are presented to demonstrate the general outputs of StimVision v2 models.

conclusionsStimVision v2 provides the opportunity to evaluate patient-specific axonal pathway activation from subthalamic DBS using anatomically detailed pathway models and electrically detailed electric field distributions with interactive adjustment of the DBS electrode position and stimulation parameter settings.

Indexed as

Deep Brain StimulationParkinson DiseaseSubthalamic NucleusAxonsHumansSoftwareAxonal pathwaysbasal gangliadriving-forceelectrodehyperdirectsubthalamic nucleus

Identifiers

PMID33389779
PMCPMC8581744
OpenAlexW3118812714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.