Evidence map›Paper›PMID 33389746›Full record

ArticleJournal of neurochemistry2021

Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia.

Drew R Seeger, Svetlana A Golovko, Bryon D Grove, Mikhail Y Golovko

Open access · greenAbstract read
In one paragraph

Article in Journal of neurochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Drew R SeegerDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA.ORCID 0000-0002-9382-2753
Svetlana A GolovkoDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA.
Bryon D GroveDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA.
Mikhail Y GolovkoDepartment of Biomedical Sciences, University of North Dakota, Grand Forks, ND, USA.ORCID 0000-0003-1749-3158
University of North Dakota · US

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
Pilot Projects CoreP30GM103329 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI GEIGER, JONATHAN DAVID · 2012 to 2016
$5.1M
Neuronal-specific fatty acid synthesis activation as protective mechanism under hypoxiaR21NS109856 · NINDS · UNIVERSITY OF NORTH DAKOTA · PI GOLOVKO, MIKHAIL Y · 2018 to 2019
$382k
NIGMS NIH HHS P20 GM113123NIGMS NIH HHS P30 GM103329NIGMS NIH HHS U54 GM128729NINDS NIH HHS R21 NS109856
6 · The paper itself

Abstract

Although cyclooxygenase (COX) role in cancer angiogenesis has been studied, little is known about its role in brain angioplasticity. In the present study, we chronically infused mice with ketorolac, a non-specific COX inhibitor that does not cross the blood-brain barrier (BBB), under normoxia or 50% isobaric hypoxia (10% O

Indexed as

Angiogenesis InhibitorsAnimalsChronic DiseaseCyclooxygenase InhibitorsDose-Response Relationship, DrugEndothelium, VascularHypoxiaHypoxia-Inducible Factor 1KetorolacMaleMiceMice, Inbred C57BLMitogensProstaglandinsSurvival AnalysisVascular Endothelial Growth Factor Receptor-2Angiogenesis InhibitorsCyclooxygenase InhibitorsHypoxia-Inducible Factor 1Kdr protein, mouseKetorolacMitogensProstaglandinsVascular Endothelial Growth Factor Receptor-2angiogenesisbraincyclooxygenasehypoxianon-steroidal anti-inflammatory drugsprostaglandins

Identifiers

PMID33389746
PMCPMC8249483
OpenAlexW3120257828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.