ArticleInfection2021
Use of rifampicin and graft removal are associated with better outcomes in prosthetic vascular graft infection.
Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Characteristics and Risk Factors for Mortality of Vascular Graft Infections: a Cohort Study.Open forum infectious diseases · 2026Article
- Efficacy of rifampicin combination therapy against MRSA prosthetic vascular graft infections in a rat model.Biofilm · 2024Article
- Characteristics and Outcome of Vascular Graft Infections: A Risk Factor and Survival Analysis.Open forum infectious diseases · 2024Article
- Fibrinolytic and antibiotic treatment of prosthetic vascular graft infections in a novel rat model.PloS one · 2023Article
- Long-term Prognosis Following Vascular Graft Infection: A 10-Year Cohort Study.Open forum infectious diseases · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesProsthetic vascular graft infection (PVGI) is a very severe disease. We aimed to determine the factors associated with treatment failure.
methodsPatients admitted to two University Hospitals with PVGI were included in this retrospective study. PVGI was classified as possible, probable or proven according to an original set of diagnostic criteria. We defined treatment failure if one of the following events occurred within the first year after PVGI diagnosis: death and infection recurrence due to the same or another pathogen.
resultsOne hundred and twelve patients were diagnosed with possible (n = 26), probable (n = 22) and proven (n = 64) PVGI. Bacterial documentation was obtained for 81% of patients. The most frequently identified pathogen was Staphylococcus aureus (n = 39). Surgery was performed in 96 patients (86%). Antibiotics were administered for more than 6 weeks in 41% of patients. Treatment failure occurred in 30 patients (27.5%). The factors associated with a lower probability of treatment failure were total removal of the infected graft (OR = 0.2, 95% CI [0.1-0.6]), rifampicin administration (OR = 0.3 [0.1-0.9]) and possible PVGI according to the GRIP criteria (OR = 0.3 [0.1-0.9]).
conclusionsTreatment failure occurred in 27.5% of patients with PVGI. Total removal of the infected graft and rifampicin administration were associated with better outcomes.
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