Evidence map›Paper›PMID 33389602›Full record

ArticleCardiovascular toxicology2021

Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.

Feyza Alyu, Yusuf Olgar, Sinan Degirmenci, Belma Turan, Yusuf Ozturk

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Uptake and Transport of Different Concentrations of PPCPs by Vegetables.International journal of environmental research and public health · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Feyza Alyu *Department of Pharmacology, Faculty of Pharmacy, Anadolu University, Yunus Emre Campus, 26470, Eskisehir, Turkey.ORCID http://orcid.org/0000-0001-9146-3841
Yusuf Olgar *Department of Biophysics, Faculty of Medicine, Ankara University, 06230, Ankara, Turkey.ORCID http://orcid.org/0000-0002-3226-7450
Sinan DegirmenciDepartment of Biophysics, Faculty of Medicine, Ankara University, 06230, Ankara, Turkey.ORCID http://orcid.org/0000-0003-4019-9459
Belma TuranDepartment of Biophysics, Faculty of Medicine, Ankara University, 06230, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2583-9294
Yusuf OzturkDepartment of Pharmacology, Faculty of Pharmacy, Anadolu University, Yunus Emre Campus, 26470, Eskisehir, Turkey. yozturk1958@gmail.com.ORCID http://orcid.org/0000-0002-9488-0891
Ankara University · TRAnadolu University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consumption of illicit pharmaceutical products containing sibutramine has been reported to cause cardiovascular toxicity problems. This study aimed to demonstrate the toxicity profile of sibutramine, and thereby provide important implications for the development of more effective strategies in both clinical approaches and drug design studies. Action potentials (APs) were determined from freshly isolated ventricular cardiomyocytes with whole-cell configuration of current clamp as online. The maximum amplitude of APs (MAPs), the resting membrane potential (RMP), and AP duration from the repolarization phases were calculated from original records. The voltage-dependent K

Indexed as

Action PotentialsAnimalsAnti-Obesity AgentsCalciumCardiotoxicityCyclobutanesHeart DiseasesHydrogen-Ion ConcentrationIsolated Heart PreparationMaleMyocytes, CardiacRatsRats, WistarReactive Oxygen SpeciesShaker Superfamily of Potassium ChannelsTime FactorsAnti-Obesity AgentsCalciumCyclobutanesReactive Oxygen SpeciesShaker Superfamily of Potassium ChannelssibutramineFluorescence microscopyLangendorff-perfused heartPatch-clamp techniquesReactive oxygen speciesSibutramine

Identifiers

PMID33389602
OpenAlexW3120988979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.