ArticleGeneral thoracic and cardiovascular surgery2021
Prospective study of recurrence at the surgical margin after wedge resection of pulmonary metastases.
Article in General thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Exploratory analysis of spread through air spaces and staple-line recurrence after wedge resection for colorectal lung metastases.Journal of thoracic disease · 2026Article
- Anatomical Versus Non-Anatomical Pulmonary Metastasectomy: European Multicentre Analysis.Cancers · 2026Article
- A retrospective evaluation of risk factors for an inadequate surgical margin in preoperative lipiodol marking for small-sized pulmonary lesions.Journal of thoracic disease · 2025Article
- Computed tomography-guided lipiodol marking enables margin-secure wedge resection for colorectal pulmonary metastases.Journal of thoracic disease · 2025Article
- Article
- Cryoablation for treatment of peripheral lung metastases from colorectal cancer: a bicenter retrospective study.European radiology · 2025Article
- Surgical Margins and Oncologic Outcomes Following Wedge Resection of Pulmonary Metastases in Pediatric and Young Adult Patients with Sarcoma.Annals of surgical oncology · 2025Article
- Multiplexed analysis of macrophage polarisation in pulmonary metastases of microsatellite stable colorectal cancer.Cancer immunology, immunotherapy : CII · 2024Article
- Oncologic Outcome after Pulmonary Metastasectomy as Part of Multidisciplinary Treatment in a Tertiary Oncological Center.Diagnostics (Basel, Switzerland) · 2023Article
- Anatomical resection of colorectal lung metastases: a reasonable indication without evidence-non-systematic and incomplete reporting is a key issue.Journal of thoracic disease · 2022Article
- Impact of the extent of lung resection on postoperative outcomes of pulmonary metastasectomy for colorectal cancer metastases: an exploratory systematic review.Journal of thoracic disease · 2022Review
- Lung Metastases: Current Surgical Indications and New Perspectives.Frontiers in surgery · 2022Review
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Authors and funding
11 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary metastasectomy is a common treatment for selected patients with pulmonary metastases. Among pulmonary resections, wedge resection is considered sufficient for pulmonary metastases. However, a major problem with wedge resection is the risk of local recurrence, especially at the surgical margin. The aim of this prospective study was to explore the frequency of and the risk factors for recurrence at the surgical margin in patients who underwent wedge resection for pulmonary metastases.
methodsBetween September 2013 and March 2018, 177 patients (220 lesions) with pulmonary metastases from 15 institutions were enrolled. We studied 130 cases (169 lesions) to determine the frequency of and risk factors associated with recurrence at the surgical margin in patients who underwent wedge resection. Moreover, we evaluated the recurrence-free rate and disease-free survival after wedge resection.
resultsA total of 81 (62.3%) patients developed recurrence. Recurrence at the surgical margin was observed in 11 of 130 (8.5%) cases. The 5-year recurrence-free rate was 89.1%. Per patient, multivariable analysis revealed that the presence of multiple pulmonary metastases was a significant risk factor for recurrence. Per tumor, distance from the surgical margin and tumor/margin ratio were risk factors for local recurrence. The 5-year disease-free survival rate was 34.7%, and the presence of multiple pulmonary metastases and small surgical margin were risk factors for disease-free survival by univariable analysis.
conclusionsAmong patients who undergo wedge resection for pulmonary metastasis, patients with multiple pulmonary metastases tend to develop recurrence at the surgical margin.
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