Evidence map›Paper›PMID 33389570›Full record

ArticleNeuromolecular medicine2021

LncRNA LINC00689 Promotes the Tumorigenesis of Glioma via Mediation of miR-526b-3p/IGF2BP1 Axis.

Wen-Liang Zhan, Ning Gao, Guo-Long Tu, Hong Tang, Ling Gao, Ying Xia

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  6. The Roles and Regulation of mBiomedicines · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wen-Liang ZhanDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China.
Ning GaoDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China.
Guo-Long TuDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China.
Hong TangDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China.
Ling GaoDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China.
Ying XiaDepartment of Neurosurgery, Affiliated Haikou Hospital at Xiangya Medical College, Central South University, No.43, People's Avenue, Haidian Island, Haikou, 570208, Hainan Province, People's Republic of China. xiaying008@163.com.ORCID 0000-0002-8519-3635
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma ranks first among the aggressive brain tumors all over the world. LncRNA LINC00689 has been confirmed to play key roles in the progression of cancers, and LINC00689 was upregulated in glioma. However, the biological function of LINC00689 in glioma is unclear. qRT-PCR was applied to detect the expressions of LINC00689 and miR-526b-3p in glioma cells. Dual-luciferase report was performed to examine the relation among LINC00689, miR-526b-3p, and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). Then, the growth, migration, and invasion of glioma cells were detected by colony formation, flow cytometry, and transwell assay, respectively. The expressions of p21, cleaved caspase 3, and MAPK signaling-related proteins in glioma cells were tested by western blotting. Finally, xenograft mice model was established to detect the effect of LINC00689 on tumor growth of glioma in vivo. LINC00689 was upregulated in glioma cells, while miR-526b-3p was downregulated. In addition, LINC00689 bound to miR-526b-3p, and IGFBP1 was targeted by miR-526b-3p. Moreover, LINC00689 knockdown or upregulation of miR-526b-3p inhibited the proliferation of glioma cells and induced the apoptosis. Consistently, the migration and invasion of glioma cells were notably reduced by LINC00689 shRNA/miR-526-3p mimics. miR-526b-3p inhibitor or IGF2BP1 upregulation could reverse the effect of LINC00689 knockdown or miR-526b-3p mimics. Finally, knockdown of LINC00689 inhibited the tumor growth of glioma in vivo through regulating miR-526b-3p/IGF2BP1/MAPK axis. In conclusion, silencing of LINC00689 could inhibit the tumorigenesis of glioma via mediation of miR-526b-3p/IGF2BP1 axis. LINC00689 may serve as a new target for the treatment of glioma.

Indexed as

AnimalsApoptosisCell Line, TumorCell MovementCell Transformation, NeoplasticGene Expression Regulation, NeoplasticGene Knockdown TechniquesGenes, ReporterGliomaHeterograftsHumansMAP Kinase Signaling SystemMiceMice, Inbred BALB CMice, NudeMicroRNAsIGF2BP1 protein, humanMicroRNAsMIRN526 microRNA, humanNeoplasm ProteinsRNA-Binding ProteinsRNA, Long NoncodingRNA, NeoplasmGliomaIGF2BP1LINC00689MAPK/ERKmiR-526b-3p

Identifiers

PMID33389570
OpenAlexW3118540152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.