ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2021
Health-related quality of life and all-cause mortality among older healthy individuals in Australia and the United States: a prospective cohort study.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Impact of physical activity and exercise training on health-related quality of life in older adults: an umbrella review.GeroScience · 2025Pooled it
- A randomized trial of a theory-driven model of health coaching for older adults: short-term and sustained outcomes.BMC primary care · 2023Trial
- Health-related quality of life trajectories and loss of independence among community-dwelling older adults.GeroScience · 2026Article
- Dietary cholesterol intake and egg consumption in relation to all-cause and cardiovascular mortality after stroke.Scientific reports · 2025Article
- Association Between Baseline Diabetes Therapy-Related Quality of Life (DTR-QOL) and Subsequent Risk of All-Cause Mortality: A Prospective Cohort Study (Diabetes Distress and Care Registry at Tenri [DDCRT 26]).Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Predictive Value of Frailty, Comorbidity, and Patient-Reported Measures for Hospitalization or Death in Older Outpatients: Quality of Life and Depression as Prognostic Red Flags.Diagnostics (Basel, Switzerland) · 2025Article
- Associations of preoperative Oswestry Disability Index and EuroQol-5D with long-term all-cause mortality in patients undergoing percutaneous vertebroplasty.Archives of medical science : AMS · 2025Article
- Longitudinal study on health-related quality of life and multimorbidity: from trajectories to outcomes in China.Frontiers in public health · 2025Article
- Walking for transport and all-cause mortality: a prospective cohort study of Australian community-dwelling older adults.BMJ public health · 2024Article
- Health-related quality of life assessed by EQ-5D-5L and its determinants among Chinese adults.Frontiers in public health · 2024Article
- Health-Related Quality of Life Scores and Values as Predictors of Mortality: A Scoping Review.Journal of general internal medicine · 2023Article
- Effects of oral health-related quality of life on total mortality: a prospective cohort study.BMC oral health · 2023Article
- Physical and mental health quality of life among underserved African American and Latino older adults.Ethnicity & health · 2023Article
- Self-Reported Early and Later Life Weight and the Risk of All-Cause Mortality in Older Adults.The journal of nutrition, health & aging · 2023Article
- Factors associated with levels of health-related quality of life in elderly women: secondary data analysis of the Korea National Health and Nutrition Examination Survey 2019.Korean journal of women health nursing · 2022Article
- Weighted Blankets' Effect on the Health of Older People Living in Nursing Homes.Geriatrics (Basel, Switzerland) · 2022Article
- The Impact of Physical Activity Levels and Functional Fitness Status on the Quality of Life Perceived by Older Adults Living in Rural and Urban Areas: The Portuguese Inland Case.Healthcare (Basel, Switzerland) · 2022Article
- Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals.Journal of Alzheimer's disease reports · 2022Article
- Health-related heterogeneity in brain aging and associations with longitudinal change in cognitive function.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
Abstract
purposePrevious research has demonstrated that lower health-related quality of life (HRQoL) is associated with higher morbidity and mortality, especially in-patient groups. The association of HRQoL with all-cause mortality in community samples requires further investigation. This study aimed to examine whether HRQoL predicts all-cause mortality in older healthy community-dwelling people from Australia and the United States (U.S.) enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) trial. We also explored whether this association varies by gender or country.
methodA prospective cohort of 19,106 individuals aged 65-98 years, who were without a dementia diagnosis or a known major life-limiting disease, and completed the 12-item short-form-HRQoL at recruitment (2010-2014). They were followed until June 2017. Cox proportional-hazard models were used to determine the association between the physical (PCS) and mental component scores (MCS) of HRQoL and all-cause mortality, adjusting for sociodemographic factors, health-related behaviours and clinical measures. Hazards ratios were estimated for every 10-unit increase in PCS or MCS.
resultsThere were 1052 deaths over a median 4.7-years (interquartile range 3.6-5.7) of follow-up, with 11.9 events per 1000 person-years. Higher PCS was associated with lower all-cause mortality (HR 0.83, 95% CI 0.77, 0.89) in the entire sample, while higher MCS was associated with lower mortality among U.S. participants only (HR 0.78, 95% CI 0.63, 0.95). Gender differences in the association of either PCS or MCS with mortality were not observed.
conclusionOur large study provides evidence that HRQoL is inversely associated with all-cause mortality among initially healthy older people.
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Registered trials
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