Evidence map›Paper›PMID 33389484›Full record

ArticleMycopathologia2021

Successful Treatment of Breakthrough Trichosporon asahii Fungemia by the Combination Therapy of Fluconazole and Liposomal Amphotericin B in a Patient with Follicular Lymphoma.

Kazuhiro Itoh, Hiromichi Iwasaki, Eiju Negoro, Hiroko Shigemi, Issei Tokimatsu, Hiroshi Tsutani, Takahiro Yamauchi

Abstract readCase Reports
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In one paragraph

Article in Mycopathologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Journal of fungi (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Fatal fungemia by biofilm-producingLe infezioni in medicina · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Kazuhiro ItohDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji-cho, Fukui, Yoshida-gun, 910-1193, Japan. kitoh@u-fukui.ac.jp.ORCID http://orcid.org/0000-0001-5574-7118
Hiromichi IwasakiDepartment of Infection Control and Prevention, University of Fukui Hospital, Fukui, Japan.
Eiju NegoroDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji-cho, Fukui, Yoshida-gun, 910-1193, Japan.
Hiroko ShigemiDepartment of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Issei TokimatsuDepartment of Medicine, Division of Clinical Infectious Diseases, School of Medicine, Showa University, Tokyo, Japan.
Hiroshi TsutaniDepartment of Internal Medicine, National Hospital Organization Awara Hospital, Fukui, Japan.
Takahiro YamauchiDepartment of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji-cho, Fukui, Yoshida-gun, 910-1193, Japan.
University of Fukui · JPKyoto Prefectural University of Medicine · JPNational Hospital Organization · JPShowa University · JPUniversity of Fukui Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive trichosporonosis is a rare and lethal fungal infection that occurs in immunocompromised patients. Breakthrough trichosporonosis can occur in patients treated with echinocandins since Trichosporon spp. are resistant to these antifungal agents. We report a case of breakthrough Trichosporon asahii fungemia. A 62-year-old Japanese woman with relapsed follicular lymphoma was treated empirically with broad-spectrum antibiotics and micafungin due to an intermittent fever during reinduction chemotherapy. After four cycles of anti-cancer chemotherapy, she experienced a high neutropenic fever and T. asahii was subsequently detected from a blood culture. The patient was not given voriconazole due to the contraindication for use with carbamazepine, and she was successfully treated with fluconazole plus liposomal amphotericin B without any serious complications. The combined therapy of fluconazole and liposomal amphotericin B may therefore be useful in treating T. asahii fungemia, especially in patients receiving antiepileptic agents.

Indexed as

FungemiaLymphoma, FollicularTrichosporonTrichosporonosisAmphotericin BAntifungal AgentsBasidiomycotaFluconazoleHumansMiddle AgedAmphotericin BAntifungal AgentsFluconazoleliposomal amphotericin BFluconazoleHematologic neoplasmsImmunocompromised hostLiposomal amphotericin BTrichosporonosis

Identifiers

PMID33389484
OpenAlexW3118401664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.