Evidence map›Paper›PMID 33389464›Full record

ArticleCellular and molecular neurobiology2022

Procalcitonin related to stroke-associated pneumonia and clinical outcomes of acute ischemic stroke after IV rt-PA treatment.

Guomei Shi, Minghao Li, Rujuan Zhou, Xiaorong Wang, Wu Xu, Feng Yang, Shouru Xue

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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  9. Simple and sensitive sandwich-like voltammetric immunosensing of procalcitonin.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guomei ShiDepartment of Neurology, The First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, Jiangsu Province, 215006, People's Republic of China.
Minghao LiDepartment of Neurology, The Taixing People's Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People's Republic of China.
Rujuan ZhouDepartment of Neurology, The Taixing People's Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People's Republic of China.
Xiaorong WangDepartment of Neurology, The Taixing People's Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People's Republic of China.
Wu XuDepartment of Neurology, The Taixing People's Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People's Republic of China.
Feng YangDepartment of Neurology, The Taixing People's Hospital, No. 1 Changzheng Road, Taixing, Jiangsu Province, 225400, People's Republic of China.
Shouru XueDepartment of Neurology, The First Affiliated Hospital of Soochow University, No. 188 Shizi Road, Suzhou, Jiangsu Province, 215006, People's Republic of China. xueshouru@suda.edu.cn.ORCID http://orcid.org/0000-0001-6028-8331
Taixing People's Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the possible relationship between procalcitonin (PCT) and stroke-associated pneumonia (SAP) as well as clinical outcomes after recombinant tissue plasminogen activator (rt-PA) treatment of AIS. From June 2015 to December 2019, 173 consecutive patients with AIS after IV rt-PA treatment were prospectively enrolled. Serum PCT concentrations were measured after admission. Multivariate logistic regression analysis was used to examine the potential risk factors of SAP, poor outcome and mortality. Of the 173 patients, 49 (28.3%) participants were identified with SAP, 87 (50.3%) with poor outcome, and 28 (16.2%) with mortality. Multivariate logistic regression analysis demonstrated that patients with PCT in the second [odds ratio (OR) 4.413; 95% confidence interval (CI) 1.331-14.634; P = 0.015] and third tertile (OR 10.958; 95% CI 3.524-34.071; P < 0.001) were more likely to have SAP compared with the first tertile. Besides, PCT was an independent predictor of 3-month poor outcome (OR 3.219, 95% CI 1.291-8.028, P = 0.007) and mortality (OR 7.538, 95% CI 2.061-27.564, P = 0.002). In receiver operating characteristic (ROC) curve analysis, the diagnostic and prognostic accuracy of PCT was higher than hs-CRP. This study demonstrated that PCT was a reliable diagnostic and prognostic biomarker of SAP and poor clinical outcomes in Chinese AIS patients after IV rt-PA treatment.

Indexed as

Brain IschemiaIschemic StrokePneumoniaStrokeHumansProcalcitoninTissue Plasminogen ActivatorTreatment OutcomeProcalcitoninTissue Plasminogen ActivatorAcute Ischemic strokeIntravenous thrombolysisOutcomesProcalcitoninStroke-associated pneumonia

Identifiers

PMID33389464
PMCPMC11421743
OpenAlexW3121063426

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.