Evidence map›Paper›PMID 33389405›Full record

ArticleBreast cancer research and treatment2021

Metabolic Syndrome: does this influence breast cancer outcomes in the triple-negative population?

Kaitlyn Kennard, Meghan E Buckley, Lina M Sizer, Sharon Larson, William B Carter, Thomas G Frazier, Ned Z Carp

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Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Metabolic Syndrome and Risks of Breast Cancer Outcomes for Luminal, Triple-Negative, and HER2-Overexpressing Subtypes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaitlyn KennardLankenau Institute for Medical Research, 100 E. Lancaster Ave, Wynnewood, PA, 19096, USA. Kaitlyn.kennard@gmail.com.ORCID http://orcid.org/0000-0001-9644-9758
Meghan E BuckleyLankenau Institute for Medical Research, 100 E. Lancaster Ave, Wynnewood, PA, 19096, USA.
Lina M SizerThe Bryn Mawr Hospital, 101 S. Bryn Mawr Avenue, Bryn Mawr, PA, 19010, USA.
Sharon LarsonLankenau Institute for Medical Research, 100 E. Lancaster Ave, Wynnewood, PA, 19096, USA.
William B CarterThe Bryn Mawr Hospital, 101 S. Bryn Mawr Avenue, Bryn Mawr, PA, 19010, USA.
Thomas G FrazierThe Bryn Mawr Hospital, 101 S. Bryn Mawr Avenue, Bryn Mawr, PA, 19010, USA.
Ned Z CarpLankenau Medical Center, 100 E. Lancaster Ave, Wynnewood, PA, 19096, USA.

Funding

Sharpe Strumia Research Foundation SSRF2019-20
6 · The paper itself

Abstract

introductionMetabolic syndrome (MS) is defined by having at least 3 of 4 components: obesity, dyslipidemia, hypertension (HTN), and diabetes. Prior studies analyzed the individual components of MS for all breast cancers which are predominantly hormone positive. Our study is the first to evaluate MS in triple-negative breast cancer (TNBC).

methodsA retrospective review of TNBC from 2007 to 2013 identified 177 patients with complete information for statistical analysis. Cox proportional hazards models were used to test the association between MS, disease-free survival (DFS), and overall survival (OS).

results48 (27%) patients had MS. After controlling for age, race, pathologic stage, surgery type, and additional comorbidities outside of MS, MS was significantly associated with poorer DFS (adjusted HR: 2.24, p = 0.030), but not associated with OS (adjusted HR: 1.92, p = 0.103). HTN was significantly associated with poorer DFS (adjusted HR: 3.63, p = 0.006) and OS (adjusted HR: 3.45, p = 0.035) in the univariable and multivariable analyses. Diabetes was not associated with worse OS or DFS. The 5-year age-adjusted OS rates for 60-year-old patients with and without diabetes were 85.8% and 87.3%, respectively. The age-adjusted 5-year OS rate for 60-year old patients was higher in patients with a body mass index (BMI) > 30 (90.2%) versus BMIs of 25-29.9 (88.2%) or < 25 (83.5%).

conclusionIn the TNBC population, MS was significantly associated with poorer DFS, but not associated with OS. HTN was the only component of MS that was significantly associated with both DFS and OS. Obesity has a potential small protective benefit in the TNBC population.

Indexed as

Breast NeoplasmsMetabolic SyndromeTriple Negative Breast NeoplasmsDisease-Free SurvivalFemaleHumansMiddle AgedPrognosisRetrospective StudiesBreast cancerHypertensionMetabolic syndromeObesityTNBCTriple-negative breast cancer

Identifiers

PMID33389405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.