Evidence map›Paper›PMID 33389381›Full record

ArticleJournal of assisted reproduction and genetics2021

Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer.

Supriya Behl, Vidhu B Joshi, Reda S Hussein, David L Walker, Kari L Lampat, Anthony G Krenik, Kathrynne M Barud, Jolene R Fredrickson, Terri M Galanits, Katherine J Rian and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Puberty Blocker and Aging Impact on Testicular Cell States and Function.bioRxiv : the preprint server for biology · 2024
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Supriya Behl *Children's Research Center, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Vidhu B Joshi *Department of Urology, Mayo Clinic, Rochester, MN, USA.
Reda S HusseinDepartment of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.
David L WalkerDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Kari L LampatDivision of Pediatric and Adolescent Gynecology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
Anthony G KrenikIn Vitro Fertilization Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Kathrynne M BarudIn Vitro Fertilization Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Jolene R FredricksonIn Vitro Fertilization Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Terri M GalanitsIn Vitro Fertilization Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Katherine J RianIn Vitro Fertilization Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Adriana M DelgadoChildren's Research Center, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Julia H ByrneChildren's Research Center, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Dean PotterDivision of Pediatric Surgery, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Siobhan T PittockDivision of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Carola A S ArndtDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Yulian ZhaoDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Patricio C GargolloDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Candace F GranbergDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Zaraq KhanDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.
Asma J ChatthaDivision of Pediatric and Adolescent Gynecology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA. Chattha.Asma@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · USMayo Clinic in Florida · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFertility is a quality of life outcome adversely affected by cancer therapy. Many childhood cancer patients, however, are not offered options to preserve their fertility. Providers acknowledge difficulty discussing impaired fertility to patients due to lack of knowledge of available options. Our objective was to review the impact of a pediatric multidisciplinary fertility preservation program on providers' fertility preservation counseling and discussion of options.

methodsA retrospective medical chart review was conducted for pediatric cancer patients prior to and following program establishment. Fertility preservation discussions, consults, and incidence were noted. Following filtering and stratification, 198 and 237 patients were seen prior to and following program establishment, respectively.

resultsFollowing program establishment, provider-patient discussions of impaired fertility (p = 0.007), fertility preservation consults (p = 0.01), and incidence of fertility preservation procedures (p < 0.001) increased among patients. Furthermore, the number of patients who received fertility preservation consults after receiving gonadotoxic treatment decreased (p < 0.001). This trend was particularly noted in pre-pubertal and female patients, for whom fertility preservation options are limited without an established program.

conclusionThe establishment of a formal program greatly improved access to fertility preservation consults and procedures in children with cancer.

Indexed as

Fertility PreservationCancer SurvivorsChildCounselingFemaleFertilityHumansInfertilityNeoplasmsPediatricsQuality of LifeReferral and ConsultationRetrospective StudiesChildhood cancerGonadotoxic treatmentGynecologyInfertilityPediatricsUrology

Identifiers

PMID33389381
PMCPMC7884554
OpenAlexW3118901434

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.