Evidence map›Paper›PMID 33389339›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2021

Conjugates of desferrioxamine and aromatic amines improve markers of iron-dependent neurotoxicity.

Rodrigo R V Carvalho, Tanara V Peres, Cleber W Liria, M Teresa Machini, Michael Aschner, Breno P Espósito

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Can iron chelators ameliorate viral infections?Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rodrigo R V CarvalhoDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil. rodrigovictor65@hotmail.com.
Tanara V PeresDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Cleber W LiriaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
M Teresa MachiniDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Breno P EspósitoDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil.
Universidade de São Paulo · BRAlbert Einstein College of Medicine · US

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
CAPES 88881.131918/2016-01FAPESP 15/14360-4FAPESP 16/03709-9FAPESP 18/19684-0NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01ES07331
6 · The paper itself

Abstract

Alzheimer's Disease (AD) is a complex neurodegenerative disorder associated in some instances with dyshomeostasis of redox-active metal ions, such as copper and iron. In this work, we investigated whether the conjugation of various aromatic amines would improve the pharmacological efficacy of the iron chelator desferrioxamine (DFO). Conjugates of DFO with aniline (DFOANI), benzosulfanylamide (DFOBAN), 2-naphthalenamine (DFONAF) and 6-quinolinamine (DFOQUN) were obtained and their properties examined. DFOQUN had good chelating activity, promoted a significant increase in the inhibition of β-amyloid peptide aggregation when compared to DFO, and also inhibited acetylcholinesterase (AChE) activity both in vitro and in vivo (Caenorhabditis elegans). These data indicate that the covalent conjugation of a strong iron chelator to an AChE inhibitor offers a powerful approach for the amelioration of iron-induced neurotoxicity symptoms.

Indexed as

AcetylcholinesteraseAminesAmyloid beta-PeptidesAnimalsAntioxidantsBiphenyl CompoundsCaenorhabditis elegansCholinesterase InhibitorsDeferoxamineHumansIron Chelating AgentsMolecular StructurePicratesProtein Aggregates1,1-diphenyl-2-picrylhydrazylAcetylcholinesteraseAminesAmyloid beta-PeptidesAntioxidantsBiphenyl CompoundsCholinesterase InhibitorsDeferoxamineIron Chelating AgentsPicratesProtein AggregatesAcetylcholinesteraseAlzheimer’s diseaseBeta amyloidCaenorhabditis elegansDesferrioxamineIron

Identifiers

PMID33389339
OpenAlexW3119560541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.