Evidence map›Paper›PMID 33389333›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2021

A novel Schiff base cobalt(III) complex induces a synergistic effect on cervical cancer cells by arresting early apoptosis stage.

Wen-Hui Liao, Xue-Qing Song, Yan-Jie Kong, Rui-Dan Bao, Fang-Fang Li, Jie Zhou, Qi-Hua Zhao, Jing-Yuan Xu, Ni Xie, Ming-Jin Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wen-Hui Liao *School of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
Xue-Qing Song *Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China.
Yan-Jie Kong *Biobank, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen, 518035, China.
Rui-Dan BaoSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
Fang-Fang LiSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
Jie ZhouSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
Qi-Hua ZhaoSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China.
Jing-Yuan XuDepartment of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, 300070, China. xujingyuan@tmu.edu.cn.
Ni XieBiobank, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen, 518035, China. xn100@szu.edu.cn.
Ming-Jin XieSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, China. mjxie@ynu.edu.cn.ORCID 0000-0001-5675-4811
Yunnan University · CNShenzhen University Health Science Center · CNTheranostics (New Zealand) · NZTianjin Medical University · CN

Funding

Applied Basic Research Foundation of Yunnan Province 2018FB134National Natural Science Foundation of China 21161022National Natural Science Foundation of China 21967019National Natural Science Foundation of China 81402206National Natural Science Foundation of China 81773149National Natural Science Foundation of China 81972003National Natural Science Foundation of China U1702283Natural Science Foundation of Guangdong Province 2017A030313668Postdoctoral Research Foundation of China 230794Sanming Project of Medicine in Shenzhen SZSM201612031Science and Technology Planning Project of Shenzhen Municipality JCYJ20170817171808368Science and Technology Planning Project of Shenzhen Municipality JCYJ20170818085657917Science and Technology Planning Project of Shenzhen Municipality JCYJ20180507184647104Science and Technology Planning Project of Shenzhen Municipality KQTD20170810160226082
6 · The paper itself

Abstract

A new schiff base cobalt(III) complex [N,N'-bis(2'-hydroxyphenylacetone)-o-ethanediamine] cobalt(III) (M3) has been synthesized and characterized by single X-ray crystallography. The cytotoxicity of complex M3 was evaluated against HeLa, LoVo, A549, A549/cis cancer cell lines, and the normal cell lines LO2 by MTT assays. The IC

Indexed as

Antineoplastic AgentsApoptosisCell ProliferationCells, CulturedCobaltCoordination ComplexesDrug Screening Assays, AntitumorFemaleHumansSchiff BasesUterine Cervical NeoplasmsAntineoplastic AgentsCobaltCoordination ComplexesSchiff BasesCell cyclec-Myc and KLF5DNA damageER stessSchiff base Co(III) complex

Identifiers

PMID33389333
OpenAlexW3119210596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.