Evidence map›Paper›PMID 33389323›Full record

ArticleAIDS and behavior2021

Trajectories of PrEP Adherence Among Young Women Aged 16 to 25 in Cape Town, South Africa.

Marie C D Stoner, Katherine B Rucinski, Danielle Giovenco, Katherine Gill, Jennifer F Morton, Linda-Gail Bekker, Connie L Celum, Ariane van der Straten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marie C D StonerWomen's Global Health Imperative, RTI International, 2150 Shattuck avenue, Berkeley, CA, 94104, USA. mcstoner@rti.org.ORCID http://orcid.org/0000-0002-7189-8669
Katherine B RucinskiSocial and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Danielle GiovencoDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Katherine GillDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Jennifer F MortonDepartment of Global Health, University of Washington, Seattle, WA, USA.
Linda-Gail BekkerDesmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Connie L CelumDepartment of Global Health, University of Washington, Seattle, WA, USA.
Ariane van der StratenWomen's Global Health Imperative, RTI International, 2150 Shattuck avenue, Berkeley, CA, 94104, USA.

Funding

Design and delivery of combination HIV prevention in young South African womenR01MH107251 · NIMH · DESMOND TUTU HIV FOUNDATION · PI BEKKER, LINDA-GAIL GAIL, CELUM, CONNIE L · 2015 to 2018
$2.0M
NIH HHS R01MH107251NIMH NIH HHS R01 MH107251
6 · The paper itself

Abstract

Despite demonstrated efficacy for HIV prevention, substantial challenges remain for the successful rollout of oral pre-exposure prophylaxis (PrEP), especially among adolescent girls and young women (AGYW). We characterized trajectories of PrEP adherence among 200 AGYW in South Africa and analyzed data from 22 qualitative interviews and 3 focus group discussions for explanatory purposes. Two adherence trajectory groups were identified: 52% with high early adherence that declined after month three and 48% with low adherence throughout. Adherence in the "consistently low" group was related to social support and logistical concerns, while the decrease in the "high declining" group corresponded to a change in the frequency of study visits from monthly to quarterly. PrEP support should be differentiated for those who need more frequent visits and adherence support initially versus later in PrEP use. Visits every month, when needed, should be considered for AGYW who need sustained support later into use.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisAdolescentFemaleHumansSafe SexSouth AfricaAnti-HIV AgentsAdherenceAdolescent girls and young womenHIV preventionPre-exposure prophylaxisTrajectory analysis

Identifiers

PMID33389323
PMCPMC8169554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.