Evidence map›Paper›PMID 33389311›Full record

ArticleLasers in medical science2021

Transoral laser microsurgery: feasibility of a new exoscopic HD-3D system coupled with free beam or fiber laser.

Andrea Luigi Camillo Carobbio, Francesco Missale, Marco Fragale, Francesco Mora, Luca Guastini, Giampiero Parrinello, Frank Rikki Mauritz Canevari, Giorgio Peretti, Leonardo S Mattos

Abstract read
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In one paragraph

Article in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Technological refinements in transoral laser exoscopic surgery: the VITOM EAGLE.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Article
  3. Applying the technology ORBEYEJournal of applied biomedicine · 2025
    Article
  4. First experience with VITOM eagle in micro-laryngeal surgery on 3D-printed laryngeal models: important improvements in exoscopic technology.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  5. Does the visual system affect the learning curve of the Otosurgeon? A cadaveric study comparing microscopy vs exoscopy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  6. Article
  7. Maximising efficiency with exoscopic surgery: a versatile approach for transoral laryngeal and oropharyngeal procedures.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Article
  8. Transoral laser exoscopic surgery of the larynx: state of the art and comparison with traditional transoral laser microsurgery.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Article
  9. 3D-exoscopic microlaryngoscopy in phonosurgery for glottic insufficiency.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  10. Article
  11. Review
  12. Transoral robotic cordectomy for glottic carcinoma: a rapid review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Andrea Luigi Camillo CarobbioIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Francesco MissaleIRCCS Ospedale Policlinico San Martino, Genoa, Italy. missale.francesco@gmail.com.ORCID http://orcid.org/0000-0002-5357-5348
Marco FragaleIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Francesco MoraIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Luca GuastiniIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giampiero ParrinelloIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Frank Rikki Mauritz CanevariIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giorgio Peretti *IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Leonardo S Mattos *Biomedical Robotics Lab, Department of Advanced Robotics, Istituto Italiano di Tecnologia, Genoa, Italy.
Ospedale Policlinico San Martino · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last decades, new technological devices and instruments have been developed to overcome the technical limits of transoral laser microsurgery. The recent introduction of 3D endoscopy seems to be a promising tool in the field of diagnostic and operative laryngology as an alternative to the traditional microlaryngoscopy. Our work aims to present a novel transoral microsurgical setting that expands the use of exoscopic systems (in this case the VITOM® 3D-HD) as an alternative to the standard operating microscope. A customized support arm and an adaptor to firmly connect the VITOM® 3D-HD camera to the laser micromanipulator were specially designed. This setup was used as an alternative to the standard operating microscope in a cohort of 17 patients affected by suspicious early to intermediate pharyngo-laryngeal neoplasms. A historical cohort of patients treated with the traditional setting and matching the same inclusion criteria was used as a reference for the duration of surgical procedures. The surgical procedures comprised 7 cordectomies, 2 endoscopic partial supraglottic laryngectomies, 4 tongue base resections, and 4 lateral oropharyngectomies or hypopharyngectomies. In 6 cases (35%), a simultaneous neck dissection was performed. The low rate of positive deep (6%) or superficial (12%) margins reinforced the safety of this platform, and the results obtained in terms of operating time were comparable to the control group (p > 0.05), which confirms the feasibility of the system. Our surgical setting setup is a convincing alternative to traditional transoral laser microsurgery for early to intermediate pharyngo-laryngeal neoplasms. The main advantages of this system are comfortable ergonomics for the first surgeon and a potential benefit in terms of teaching if applied in university hospitals, since the entire surgical team can view the same surgical 3D-HD view of the first operator. Further work is still needed to objectively compare the traditional and new technique, and to validate our preliminary clinical findings.

Indexed as

Laryngeal NeoplasmsLaser TherapyFeasibility StudiesHumansLasersMicrosurgeryRetrospective StudiesCO2 laserExoscopeLaryngeal cancerOropharyngeal cancerTLMTOLMSVitom 3D

Identifiers

PMID33389311
OpenAlexW3121057204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.