Evidence map›Paper›PMID 33389285›Full record

ReviewCancer metastasis reviews2021

Potential mechanisms of tumor progression associated with postoperative infectious complications.

Hironori Tsujimoto, Minako Kobayashi, Hidekazu Sugasawa, Satoshi Ono, Yoji Kishi, Hideki Ueno

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Preoperative PD-1Oncology letters · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Prognostic value ofEsophagus : official journal of the Japan Esophageal Society · 2023
    Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hironori TsujimotoDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan. tsujihi@ndmc.ac.jp.ORCID http://orcid.org/0000-0002-2808-4723
Minako KobayashiDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.
Hidekazu SugasawaDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.
Satoshi OnoDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.
Yoji KishiDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, 359-8513, Japan.
National Defense Medical College · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence that postoperative infectious complications (PICs) are associated with poor prognosis after potentially curative surgery. However, the role that PICs play in tumor development remains unclear. In this article, we reviewed the literature for novel insights on the mechanisms of cancer progression associated with PICs. The Medline and EMBASE databases were searched for publications regarding the role of suppression of antitumor immunity by PIC in tumor progression and selected 916 manuscripts were selected for this review. In addition, a summary of the authors' own experimental data from this field was set in the context of current knowledge regarding cancer progression under septic conditions. Initially, sepsis/microbial infection dramatically activates the systemic immune system with increases in pro-inflammatory mediators, which results in the development of systemic inflammatory response syndrome; however, when sepsis persists in septic patients, a shift toward an anti-inflammatory immunosuppressive state, characterized by macrophage deactivation, reduced antigen presentation, T cell anergy, and a shift in the T helper cell pattern to a predominantly TH2-type response, occurs. Thus, various cytokine reactions and the immune status dynamically change during microbial infection, including PIC. We proposed three possible mechanisms for the tumor progression associated with PIC: first, a mechanism in which microbes and/or microbial PAMPs may be directly involved in cancer growth; second, a mechanism in which factors released from immunocompetent cells during infections may affect tumor progression; and third, a mechanism in which factors suppress host tumor immunity during infections, which may result in tumor progression. A more detailed understanding by surgeons of the immunological features in cancer patients with PIC can subsequently open new avenues for improving unfavorable long-term oncological outcomes associated with PICs.

Indexed as

NeoplasmsPostoperative ComplicationsCytokinesDisease ProgressionHumansInfectionsInflammation MediatorsMacrophagesTh2 CellsCytokinesInflammation MediatorsCytokinePostoperative infectionSepsisTumor progression

Identifiers

PMID33389285
OpenAlexW3119634766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.