Evidence map›Paper›PMID 33389144›Full record

ArticleEuropean journal of applied physiology2021

Functional evidence of low-pressure cardiopulmonary baroreceptor reinnervation 1 year after heart transplantation.

Vegard Bruun Bratholm Wyller, Sissel Nygaard, Anders Haugom Christensen, Katrine Rolid, Kari Nytrøen, Lars Gullestad, Arnt Fiane, Erik Thaulow, Gaute Døhlen, J Philip Saul

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In one paragraph

Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Nerve regeneration in transplanted organs and tracer imaging studies: A review.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Vegard Bruun Bratholm WyllerDepartment of Pediatrics, Akershus University Hospital, 1478, Lørenskog, Norway. v.b.b.wyller@medisin.uio.no.ORCID http://orcid.org/0000-0002-2537-7782
Sissel NygaardFaculty of Medicine, University of Oslo, Oslo, Norway.
Anders Haugom ChristensenFaculty of Medicine, University of Oslo, Oslo, Norway.
Katrine RolidFaculty of Medicine, University of Oslo, Oslo, Norway.
Kari NytrøenFaculty of Medicine, University of Oslo, Oslo, Norway.
Lars GullestadFaculty of Medicine, University of Oslo, Oslo, Norway.
Arnt FianeDepartment of Cardiothoracic Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Erik ThaulowDepartment of Pediatric Cardiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Gaute DøhlenDepartment of Pediatric Cardiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
J Philip SaulDepartment of Pediatrics, West Virginia University, Morgantown, WV, USA.
Oslo University Hospital · NOUniversity of Oslo · NOWest Virginia University · US

Funding

Helse Sør-Øst RHF 2012044
6 · The paper itself

Abstract

purposeHeart transplantation (HTx) implies denervation of afferent neural connections. Reinnervation of low-pressure cardiopulmonary baroreceptors might impact the development and treatment of hypertension, but little is known of its occurrence. The present prospective study investigated possible afferent reinnervation of low-pressure cardiopulmonary baroreceptors during the first year after heart transplantation.

methodsA total of 50 heart transplant recipients (HTxRs) were included and were evaluated 7-12 weeks after transplant surgery, with follow-up 6 and 12 months later. In addition, a reference group of 50 healthy control subjects was examined once. Continuous, non-invasive recordings of cardiovascular variables were carried out at supine rest, during 15 min of 20° head-up tilt, during Valsalva maneuver and during 1 min of 30% maximal voluntary handgrip. In addition, routine clinical data including invasive measurements were used in the analyses.

resultsDuring the first year after HTx, the heart rate (HR) response to 20° head-up tilt partly normalized, a negative relationship between resting mean right atrial pressure and HR tilt response developed, low-frequency variability of the RR interval and systolic blood pressure at supine rest increased, and the total peripheral resistance response to Valsalva maneuver became stronger.

conclusionFunctional assessments suggest that afferent reinnervation of low-pressure cardiopulmonary receptors occurs during the first year after heart transplantation, partially restoring reflex-mediated responses to altered cardiac filling.

Indexed as

Heart TransplantationCardiovascular SystemFemaleHand StrengthHeart RateHumansLungMaleMiddle AgedPressoreceptorsProspective StudiesAutonomic cardiovascular controlCardiopulmonary receptorsDenervationHeart transplantation

Identifiers

PMID33389144
OpenAlexW3119583882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.