SynthesisActa diabetologica2021
Type 2 diabetes mellitus and risk of head and neck cancer subtypes: a systematic review and meta-analysis of observational studies.
Synthesis in Acta diabetologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Diabetes is associated with elevated mortality, stroke, and osteoradionecrosis in squamous cell carcinomas of the head and neck: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Association Between Metabolic Syndrome and Its Components and the Risk of Head and Neck Cancer: A Systematic Review and Meta-Analysis.Cancer medicine · 2025Pooled it
- Type 2 Diabetes Risk Among Older Asian, Native Hawaiian and Pacific Islander Patients With Head and Neck Cancer in the United States.Cancer medicine · 2026Article
- Association Between Type 2 Diabetes and Viruses with Oncomodulatory Activity in Patients with Squamous Cell Carcinoma.Current issues in molecular biology · 2026Article
- Impact of diabetes mellitus in patients undergoing radiation therapy for head and neck cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- Dissecting the causal pathway linking HbA1c to oral cavity cancer via immune cell modulation: a bidirectional mendelian randomization analysis.Frontiers in oncology · 2026Article
- Incidence, Risk Factors, and Epidemiological Trends of Head and Neck Cancer: A Global Analysis.MedComm · 2025Article
- The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses.Frontiers in genetics · 2025Article
- Connection between oral health and chronic diseases.MedComm · 2025Review
- [Impact of type 2 diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Association between Metabolic Syndrome and Risk of Hypopharyngeal Cancer: A Nationwide Cohort Study from Korea.Cancers · 2023Article
- H1-antihistamine use and head and neck cancer risk in type 2 diabetes mellitus.Oncology research · 2023Article
- Adherence to diabetes risk reduction diet and the risk of head and neck cancer: a prospective study of 101,755 American adults.Frontiers in nutrition · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aimsThe association between type 2 diabetes mellitus (T2DM) and risk of head and neck cancer (HNC) remains unclear. This study aims to perform a system review and meta-analysis to explore this relationship.
methodsPubMed, Web of Science, and Embase databases were searched for studies published up to July 31, 2020, regarding the association between T2DM and HNC risk. A random-effects model was utilized to calculate summary relative risks (RRs) with corresponding 95% confidence intervals (CIs).
resultsFourteen case-control studies and thirteen cohort studies were included in our analysis. We observed a weak association between T2DM and risk of HNC overall, but there was no statistical significance (RR, 1.04; 95% CI, 0.88-1.23; I
conclusionsThis meta-analysis indicates that T2DM is associated with an increased risk of HNC in East Asia. As for site-specific cancer types, the risk of oral cancer was significantly increased in T2DM patients, which appear to be mediated or confounded by smoking, alcohol use, or BMI/obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.