SynthesisPediatric nephrology (Berlin, Germany)2021
Neutrophil gelatinase-associated lipocalin for urinary tract infection and pyelonephritis: a systematic review.
Synthesis in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Accuracy of NGAL as a Biomarker for Urinary Tract Infection in Young Febrile Children: An Individual Patient Data Meta-Analysis.The Journal of pediatrics · 2023Pooled it
- Differential Effects of Uropathogenic and Non-UropathogenicResearch and reports in urology · 2026Article
- Accuracy of Screening Tests for the Diagnosis of Urinary Tract Infections in Young Children.Pediatrics · 2024Article
- Ramifications of requiring pyuria for the diagnosis of urinary tract infection.Acta paediatrica (Oslo, Norway : 1992) · 2024Article
- Current and emerging strategies to curb antibiotic-resistant urinary tract infections.Nature reviews. Urology · 2024Review
- Persistent Elevation in Urinary Neutrophil Gelatinase-Associated Lipocalin Levels Can Be a Predictor of Urinary Tract Infection Recurrence or Persistence in Women.International journal of molecular sciences · 2024Article
- Assessment of urine calprotectin and YKL-40 levels in urinary tract infection diagnosis in children under 2 years of age.Scientific reports · 2024Article
- Biomarkers for urinary tract infection: present and future perspectives.Pediatric nephrology (Berlin, Germany) · 2024Review
- Plasma and Urinary Neutrophil Gelatinase-Associated Lipocalin as Predictors of Renal Parenchymal Involvement in Children with Febrile Urinary Tract Infection: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study.Pediatric nephrology (Berlin, Germany) · 2024Article
- Assessment of Urinary and Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels as Novel Predictors for Vesicoureteral Reflux Diagnosis in Children with Febrile Urinary Tract Infection.Medical journal of the Islamic Republic of Iran · 2024Article
- Support for the Use of a New Cutoff to Define a Positive Urine Culture in Young Children.Pediatrics · 2023Article
- Urine specific gravity, pyuria, and neutrophil gelatinase-associated lipocalin for identifying urinary tract infection in young children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Biomarkers for febrile urinary tract infection in children.Frontiers in pediatrics · 2023Article
- Biomarkers for febrile urinary tract infection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe sensitivity and specificity of the leukocyte esterase test are relatively low for a screening test for urinary tract infection (UTI). More accurate tests could reduce both overtreatment and missed cases. This study aimed to determine whether neutrophil gelatinase-associated lipocalin (NGAL) can replace leukocyte esterase in the diagnosis of UTI and/or whether NGAL accurately identifies children with acute pyelonephritis.
methodsData sources-MEDLINE and EMBASE. We only considered published studies that evaluated the results of an index test (NGAL) against the results of urine culture (for UTI) or against the results of dimercaptosuccinic acid (for acute pyelonephritis) in children aged 0 to 18 years. Two authors independently applied the selection criteria to all citations and independently extracted the data.
resultsA total of 12 studies met our inclusion criteria. Four studies (920 children) included data on NGAL for UTI; eight studies (580 children) included data on NGAL for pyelonephritis. We did not pool accuracy values because the included studies used different cutoff values. For the diagnosis of UTI, urinary NGAL appeared to have better accuracy than the leukocyte esterase test in all included studies. For the diagnosis of pyelonephritis, neither plasma NGAL nor urinary NGAL had high sensitivity and/or specificity. The number of studies was the main limitation of this systematic review.
conclusionsUrinary NGAL appears promising for the diagnosis of UTI; however, larger studies are needed to validate this marker as a replacement for leukocyte esterase. The use of NGAL for diagnosing acute pyelonephritis requires further study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.