Evidence map›Paper›PMID 33389084›Full record

ArticleEuropean journal of nutrition2021

Ten days of complete fasting affected subjective sensations but not cognitive abilities in healthy adults.

Chao Yang, Qianying Ma, Hongyu Zhang, Feng Wu, Manrui Wu, Chengjia Yang, Ying Chen, Jianghui Xiong, Wenjuan Liu, Hailong Wang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chao Yang *State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China.
Qianying Ma *Department of Psychology, Beihang University, No. 37, Xueyuan Road, Haidian District, Beijing, 100083, China.
Hongyu Zhang *State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China.
Feng WuState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China.
Manrui WuDepartment of Psychology, Beihang University, No. 37, Xueyuan Road, Haidian District, Beijing, 100083, China.
Chengjia YangState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China.
Ying ChenLab of Epigenetics and Health Technology, SPACEnter Space Science and Technology Institute, Shenzhen, China.
Jianghui XiongLab of Epigenetics and Health Technology, SPACEnter Space Science and Technology Institute, Shenzhen, China.
Wenjuan LiuBeijing Ziyuan Fasting Training Center, Beijing, China.
Hailong WangState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China.
Ruilin WuDepartment of Psychology, Beihang University, No. 37, Xueyuan Road, Haidian District, Beijing, 100083, China. wuruilin@buaa.edu.cn.
Zhongquan DaiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China. daizhq77@163.com.ORCID http://orcid.org/0000-0002-6152-6407
Yinghui LiState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, No. 26, Beiqing Road, Haidian District, P.O. Box 5132-15, Beijing, 100094, China. yinghuidd@vip.sina.com.

Funding

Advanced Space Medico-Engineering Research Project of China 18035020103National Natural Science Foundation of China 31470832National Natural Science Foundation of China 81801872Shenzhen Science & Technology Program CKFW2016082915204709Space Medical Experiment Project of China Manned Space Program HYZHXM01002State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center SMFA17A02State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center SMFA17B04State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center SMFA17B06State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center SMFA18B02State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center SMFA18B06
6 · The paper itself

Abstract

purposePeople may be unable to obtain anything edible for days under some circumstances, but they must maintain their calmness and cognition to navigate solutions. Our aim was to study changes in subjective sensations and cognition in healthy adults during a 10-day complete fasting experiment.

methodsThirteen healthy male volunteers voluntarily participated in the 22-day experiment comprising 4 phases: 3 days of baseline consumption, 10 days of complete fasting (only water ad libitum), 4 days of calorie restriction, and a 5-day recovery period. The volunteers' subjective sensations, cognitive performance, and serum energy substances were measured at 6 time points.

resultsAcross the 6 time points, the trajectories of subjective sensations in response to fasting were "U"- or " ∩ "-shaped curves instead of progressive discomfort or mood enhancement. A significant fasting time effect was found on depression-dejection (baseline: 16.85 ± 2.88; highest score on the third day of completing fasting: 17.69 ± 3.97, P = 0.04) and self-rated anxiety (baseline: 26.23 ± 4.75; highest score on the sixth day of completing fasting: 30.85 ± 5.58, P = 0.01), and the change curves were consistent with the inflection point of the energy substrates shifting from serum glucose to ketone. In addition, basic cognitive functions appeared to be unaffected during the 10-day fast.

conclusionsOur study showed strong influences on the sensations from the third to sixth days of the prolonged fasting period but no significant effects on basic cognitive abilities associated with the energy substance switch. These findings could contribute to the development and understanding of survival strategies in food-shortage emergencies or of intermittent fasting programmes.

Indexed as

CognitionFastingAdultAffectCaloric RestrictionEnergy IntakeHumansMaleSensationCognitiveEmotionFastingHealthySubjective sensations

Identifiers

PMID33389084

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.