Evidence map›Paper›PMID 33388926›Full record

SynthesisJournal of neurology2022

Migraine in transient global amnesia: a meta-analysis of observational studies.

Ioannis Liampas, Athanasios S Siouras, Vasileios Siokas, Zisis Tsouris, Dimitrios Rikos, Alexandros Brotis, Athina-Maria Aloizou, Metaxia Dastamani, Efthimios Dardiotis

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. Review
  12. Chronobiology of transient global amnesia.Journal of neurology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ioannis LiampasDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece. liampasioannes@gmail.com.ORCID http://orcid.org/0000-0002-2958-5220
Athanasios S SiourasDepartment of Computer Science and Biomedical Informatics, School of Science, University of Thessaly, Lamia, Greece.
Vasileios SiokasDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Zisis TsourisDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Dimitrios RikosDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Alexandros BrotisDepartment of Neurosurgery, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Athina-Maria AloizouDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Metaxia DastamaniDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
Efthimios DardiotisDepartment of Neurology, School of Medicine, University Hospital of Larissa, University of Thessaly, Larissa, Greece.
University of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPURPOSE: Although many studies have investigated the relationship between transient global amnesia (TGA) and migraine, to date, no meta-analysis has confirmed the existence and size of their association. METHODOLOGY: Literature search involved MEDLINE, EMBASE, CENTRAL and PsycINFO. Observational controlled studies including TGA patients (Caplan, Hodges and Warlow) were retrieved. Quality evaluation was based on the Newcastle-Ottawa scale. The prevalence of migraine was compared in TGA patients vs. healthy controls (HC), as well as in TGA against TIA individuals. Data from case-control, cross-sectional and cohort studies were pooled separately.

resultsLiterature search yielded 1178 articles, 12 of which were included in the present meta-analysis. Results from case-control (ten), cohort (one) and cross-sectional (one) studies were compatible with an association between TGA and migraine. The nationwide inpatient cross-sectional study was of lesser value due to its inpatient orientation. The high-quality, population-based, retrospective cohort (158,301 participants per group) determined a higher relative-risk (RR) of TGA for migraine vs. non-migraine individuals [RR = 2.48, 95%confidence-interval (95% CI) = (1.32, 4.87)]. Sensitivity testing based on stricter diagnostic criteria strengthened the estimated association [RR = 3.84, 95% CI = (1.57, 9.38)]. Additionally, pooled data from eight case-control studies (700 TGA, 746 HC) yielded similar results [Odds-Ratio, OR = 2.51, 95% CI = (1.85, 3.41)], with the association mainly driven by the three high-quality studies, rather than the five articles of moderate quality. Finally, pooled findings from four case-control studies of moderate-quality revealed a higher prevalence of migraine among TGA compared to TIA patients [OR = 1.82, 95% CI = (1.22, 2.73)].

conclusionsA significant association between TGA and migraine was established. The underlying connecting mechanism remains undetermined, yet.

Indexed as

Amnesia, Transient GlobalMigraine DisordersAmnesiaCase-Control StudiesCross-Sectional StudiesHumansRetrospective StudiesAuraMigraineTransient global amnesiaTransient ischemic attack

Identifiers

PMID33388926
OpenAlexW3120679095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.