Evidence map›Paper›PMID 33388785›Full record

Observational studyEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2022

Blood transfusion in major emergency abdominal surgery.

Anders Schack, Sarah Ekeloef, Sisse Rye Ostrowski, Ismail Gögenur, Jakob Burcharth

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Cell Salvage Using the Autotransfusion Device CATSmartTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anders SchackCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital and University of Copenhagen, Lykkebaekvej 1, DK-4600, Køge, Denmark. andersemilschack@gmail.com.ORCID http://orcid.org/0000-0002-9280-0384
Sarah EkeloefCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital and University of Copenhagen, Lykkebaekvej 1, DK-4600, Køge, Denmark.
Sisse Rye OstrowskiDepartment of Clinical Immunology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Ismail GögenurCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital and University of Copenhagen, Lykkebaekvej 1, DK-4600, Køge, Denmark.
Jakob BurcharthCenter for Surgical Science (CSS), Department of Surgery, Zealand University Hospital and University of Copenhagen, Lykkebaekvej 1, DK-4600, Køge, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor emergency abdominal surgery is associated with excess mortality. Transfusion is known to be associated with increased morbidity and emergency surgery is an independent risk factor for perioperative transfusion. The primary objectives of this study were to identify risk factors for transfusion, and secondarily to investigate the influence of transfusion on clinical outcomes after major emergency abdominal surgery. STUDY DESIGN AND

methodsThis study combined retrospective observational data including intraoperative, postoperative, and transfusion data in patients undergoing major emergency abdominal surgery from January 2010 to October 2016 at a Danish university hospital. The primary outcome was a transfusion of any kind from initiation of surgery to postoperative day 7. Secondary outcomes included 7-, 30-, 90-day and long-term mortality (median follow-up = 34.6 months, IQR = 13.0-58.3), lengths of stay, and surgical complication rate (Clavien-Dindo score ≥ 3a).

resultsA total of 1288 patients were included and 391 (30%) received a transfusion of any kind. Multivariate logistic regression identified age, hepatic comorbidity, cardiac comorbidity, post-surgical anemia, ADP-receptor inhibitors, acetylsalicylic acid, anticoagulants, and operation type as risk factors for postoperative transfusion. 60.1% of the transfused patients experienced a serious surgical complication within 30 days of surgery compared with 28.1% of the non-transfused patients (p < 0.001). Among patients receiving a postoperative transfusion, unadjusted long-term mortality was increased with a hazard ratio of 3.8 (95% CI 2.9-5.0), p < 0.01. Transfused patients had significantly higher mortality at 7-, 30-, 90- and long-term, as well as a longer hospital stay but in the multivariate analyses, transfusion was not associated with mortality.

conclusionPeri- and postoperative transfusion in relation to major emergency abdominal surgery was associated with an increased risk of postoperative complications. The potential benefits and harms of blood transfusion and clinical significance of pre- and postoperative anemia after major emergency abdominal surgery should be further studied in clinical prospective studies.

Indexed as

AbdomenBlood TransfusionHumansLength of StayPostoperative ComplicationsProspective StudiesRetrospective StudiesRisk FactorsBlood transfusionEmergency surgeryGeneral surgerySurvival

Identifiers

PMID33388785
OpenAlexW3118907579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.