Evidence map›Paper›PMID 33388776›Full record

ReviewEndocrine reviews2021

Praegnatio Perturbatio-Impact of Endocrine-Disrupting Chemicals.

Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrine reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 91 citations in OpenAlex.

  1. Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
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  10. Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  11. Article
  12. Article
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  15. Article
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  18. Review
  19. Article
  20. Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8443-7212
Wenhui SongDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Muraly PuttabyatappaDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1374-7619
University of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
ENVIRONMENTAL TOXICOLOGY PRE/POST DOCTORAL RES.TRAININGT32ES007062 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 1985 to 2026
$10.5M
Project 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEEKER, JOHN D., PADMANABHAN, VASANTHA · 2013 to 2018
$3.9M
Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic healthR01ES030374 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EVANS, NEIL PRICE, LEA, RICHARD · 2020 to 2024
$2.3M
NIDDK NIH HHS P30 DK020572NIEHS NIH HHS P01 ES022844NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES030374NIEHS NIH HHS T32 ES007062
6 · The paper itself

Abstract

The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes-a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.

Indexed as

Endocrine DisruptorsPremature BirthAdultFemaleHumansInfant, NewbornMaternal ExposurePregnancyEndocrine Disruptorsbirth outcomesendocrine-disrupting chemicalsplacentapregnancy

Identifiers

PMID33388776
PMCPMC8152448
OpenAlexW3120509918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.