ReviewCurrent opinion in neurobiology2021
Dynamic and heterogeneous neural ensembles contribute to a memory engram.
Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.Annual review of neuroscience · 2026Review
- Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Transcriptomic signatures of hippocampal active place avoidance memory maintenance.Frontiers in cellular neuroscience · 2026Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Immediate-early genes Arc and c-Fos show divergent brain-wide expression following contextual fear conditioning.Communications biology · 2025Article
- Alprazolam induces anterograde amnesia for contextual fear memory and alters dorsoventral hippocampal neuronal ensembles in female mice.Scientific reports · 2025Article
- Evolving Engrams Demand Changes in Effective Cues.Hippocampus · 2025Review
- An improved FLARE system for recording and manipulating neuronal activity.Cell reports methods · 2025Article
- Erasable hippocampal neural signatures predict memory discrimination.Cell reports · 2025Article
- A Cocaine-Activated Ensemble Exerts Increased Control Over Behavior While Decreasing in Size.Biological psychiatry · 2025Article
- An improved FLARE system for recording and manipulating neuronal activity.bioRxiv : the preprint server for biology · 2025Article
- Erasable Hippocampal Neural Signatures Predict Memory Discrimination.bioRxiv : the preprint server for biology · 2024Article
- Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging.Molecular brain · 2024Article
- Memory engram stability and flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Optogenetic inhibition of light-captured alcohol-taking striatal engrams facilitates extinction and suppresses reinstatement.Alcohol, clinical & experimental research · 2024Article
- Spatially Resolved Transcriptomic Signatures of Hippocampal Subregions andbioRxiv : the preprint server for biology · 2024Article
- A Semi-supervised Pipeline for Accurate Neuron Segmentation with Fewer Ground Truth Labels.eNeuro · 2024Article
- Spatially resolved transcriptomic signatures of hippocampal subregions andFrontiers in molecular neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In the century since the notion of the 'engram' was first introduced to describe the physical manifestation of memory, new technologies for identifying cellular activity have enabled us to deepen our understanding of the possible physical substrate of memory. A number of studies have shown that memories are stored in a sparse population of neurons known as a neural ensemble or engram cells. While earlier investigations highlighted that the stability of neural ensembles underlies a memory representation, recent studies have found that neural ensembles are more dynamic and fluid than previously understood. Additionally, a number of studies have begun to dissect the cellular and molecular diversity of functionally distinct subpopulations of cells contained within an engram. We propose that ensemble fluidity and compositional heterogeneity support memory flexibility and functional diversity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.