ArticleProgress in neurobiology2021
Mechanism of seizure-induced retrograde amnesia.
Article in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- The Burden of Epilepsy: The Contribution of Seizures (AES 2025 Presidential Symposium).Epilepsy currents · 2026Article
- Perirhinal cortex gains control of hippocampal seizures via broad downstream circuits in male mouse models.Nature communications · 2026Article
- Altered Physiology and Ensemble Recruitment of Dentate Gyrus Semilunar Granule Cells in a Mouse Model of Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hyperactive neuronal networks enhance tau spread in an Alzheimer's disease mouse model.bioRxiv : the preprint server for biology · 2025Article
- Status epilepticus: Updates on mechanisms and treatments.Epilepsia open · 2025Review
- Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear-Conditioned Responses.Bioelectromagnetics · 2025Article
- Article
- Chemogenetic Breakdown of the Dentate Gate Causes Seizures and Spatial Memory Deficits.bioRxiv : the preprint server for biology · 2024Article
- Interictal spikes during spatial working memory carry helpful or distracting representations of space and have opposing impacts on performance.bioRxiv : the preprint server for biology · 2024Article
- Associating sensory cues with incoming seizures: developing an animal model of auras.Scientific reports · 2024Article
- Anatomical Substrates of Rapid Eye Movement Sleep Rebound in a Rodent Model of Post-sevoflurane Sleep Disruption.Anesthesiology · 2024Article
- Amnesia after Repeated Head Impact Is Caused by Impaired Synaptic Plasticity in the Memory Engram.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes.Brain : a journal of neurology · 2024Article
- Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures.The Journal of clinical investigation · 2024Article
- Neuronal plasticity contributes to postictal death.Progress in neurobiology · 2023Article
- Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model.Acta pharmacologica Sinica · 2023Article
- Unearthing the mechanisms of responsive neurostimulation for epilepsy.Communications medicine · 2023Review
- The recycling of AMPA receptors/GABAa receptors is related to neuronal excitation/inhibition imbalance and may be regulated by KIF5A.Annals of translational medicine · 2022Article
- Neuronal activity mapping during exploration of a novel environment.Brain research · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Seizures cause retrograde amnesia, but underlying mechanisms are poorly understood. We tested whether seizure activated neuronal circuits overlap with spatial memory engram and whether seizures saturate LTP in engram cells. A seizure caused retrograde amnesia for spatial memory task. Spatial learning and a seizure caused cFos expression and synaptic plasticity overlapping set of neurons in the CA1 of the hippocampus. Recordings from learning-labeled CA1 pyramidal neurons showed potentiated synapses. Seizure-tagged neurons were also more excitable with larger rectifying excitatory postsynaptic currents than surrounding unlabeled neurons. These neurons had enlarged dendritic spines and saturated LTP. A seizure immediately after learning, reset the memory engram. Seizures cause retrograde amnesia through shared ensembles and mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.