Evidence map›Paper›PMID 33387660›Full record

ArticleNeuroscience letters2021

β-endorphin at the intersection of pain and cancer progression: Preclinical evidence.

Donovan A Argueta, Anupam Aich, Jianxun Lei, Stacy Kiven, Aithanh Nguyen, Ying Wang, Joshua Gu, Weian Zhao, Kalpna Gupta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Donovan A ArguetaHematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
Anupam AichHematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
Jianxun LeiDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Stacy KivenHematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
Aithanh NguyenDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Ying WangDivision of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Anesthesia, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Joshua GuSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, CA, USA.
Weian ZhaoSue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, CA, USA; Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA; Edwards Life Sciences Center for Advanced Cardiovascular Technology, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Kalpna GuptaHematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Southern California Institute for Research and Education, VA Medical Center, Long Beach, CA, USA. Electronic address: kalpnag@hs.uci.edu.
University of California, Irvine · USUniversity of Minnesota · US

Funding

Cannabinoid-based therapy and approaches to quantify pain in sickle cell diseaseU01HL117664 · NHLBI · UNIVERSITY OF MINNESOTA · PI GUPTA, KALPNA · 2013 to 2018
$9.6M
Targeting mechanisms contributing to vascular dysfunction and pain in sickle cell diseaseR01HL147562 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GUPTA, KALPNA · 2019 to 2022
$3.4M
Treating pain in sickle cell disease by means of focused ultrasound neuromodulationU18EB029354 · NIBIB · CARNEGIE-MELLON UNIVERSITY · PI HE, BIN · 2019 to 2019
$2.0M
NHLBI NIH HHS R01 HL147562NHLBI NIH HHS U01 HL117664NIBIB NIH HHS U18 EB029354
6 · The paper itself

Abstract

We examined the association between endogenous opioid β-endorphin, cancer progression and pain in a transgenic mouse model of breast cancer, with a rat C3(1) simian virus 40 large tumor antigen fusion gene (C3TAg). C3TAg mice develop ductal epithelial atypia at 8 weeks, progression to intra-epithelial neoplasia at 12 weeks, and invasive carcinoma with palpable tumors at 16 weeks. Consistent with invasive carcinoma at 4 months of age, C3TAg mice demonstrate a significant increase in hyperalgesia compared to younger C3TAg or control FVBN mice without tumors. Our data show that the growing tumor contributes to circulating β-endorphin. As an endogenous ligand of mu opioid receptor, β-endorphin has analgesic activity. Paradoxically, we observed an increase in pain in transgenic breast cancer mice with significantly high circulating and tumor-associated β-endorphin. Increased circulating β-endorphin correlates with increasing tumor burden. β-endorphin induced the activation of mitogenic and survival-promoting signaling pathways, MAPK/ERK 1/2, STAT3 and Akt, observed by us in human MDA-MB-231 cells suggesting a role for β-endorphin in breast cancer progression and associated pain.

Indexed as

Disease ProgressionAnimalsbeta-EndorphinBiomarkersBreast NeoplasmsCancer PainCell Line, TumorFemaleHumansMiceMice, Transgenicbeta-EndorphinBiomarkersBreast cancerMorphineOpioidPainβ-Endorphin

Identifiers

PMID33387660
PMCPMC7837276
OpenAlexW3118139805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.