ArticleAnnals of vascular surgery2021
Endotheliitis in Coronavirus Disease 2019-Positive Patients After Extremity Amputation for Acute Thrombotic Events.
Article in Annals of vascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- COVID-19 and peripheral arterial complications in people with diabetes and hypertension: A systematic review.Diabetes & metabolic syndromePooled it
- Elevated amputation rates in COVID-19 survivors: Insights from a large-scale Japanese cohort study.Journal of diabetes investigation · 2025Article
- Impact of COVID-19 on Thrombotic Complications in Microsurgery: Deep Inferior Epigastric Perforator Flap Outcomes Amid Pandemic.Plastic and reconstructive surgery. Global open · 2025Article
- The influence of SARS-CoV-2 vaccination on post-operative outcomes in microsurgery patients.Microsurgery · 2022Article
- Management of Acute Limb Ischaemia Due to COVID-19 Induced Arterial Thrombosis: A Multi-Centre Indian Experience.Annals of vascular diseases · 2022Article
- True Aneurysm on Posterior Tibial Artery as Late Complication of SARS-CoV-2.Annals of vascular surgery · 2022Article
- Editor's Choice - Update of the European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia in Light of the COVID-19 Pandemic, Based on a Scoping Review of the Literature.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2022Article
- A review of acute limb ischemia in COVID-positive patients.Seminars in vascular surgery · 2021Review
- Re: "Endothelitis in COVID-19-Positive Patients after Extremity Amputation for Acute Thrombotic Events".Annals of vascular surgery · 2021Article
- miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells.Non-coding RNA · 2021Article
- miR-24 targets SARS-CoV-2 co-factor Neuropilin-1 in human brain microvascular endothelial cells: Insights for COVID-19 neurological manifestations.Research square · 2021Article
- Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury.Frontiers in immunologyReview
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth arterial and venous thrombotic events of the extremities occur in coronavirus disease 2019 (COVID-19) infection, but the etiology of these events remains unclear. This study sought to evaluate pathology specimens of COVID-19-positive patients postamputation, who were found to have Rutherford 3 acute limb ischemia requiring amputation.
methodsA retrospective review was performed of all vascular surgery emergency room and inpatient consultations in patients who presented to the Mount Sinai Health System from March 26, 2020, to May 10, 2020. Pathology specimens were examined using hematoxylin and eosin stain. The specimens were assessed for the following: inflammatory cells associated with endothelium/apoptotic bodies, mononuclear cells, small vessel congestion, and lymphocytic endotheliitis. Of the specimens evaluated, 2 patients with a known history of peripheral vascular disease were excluded.
resultsInflammatory cells associated with endothelium/apoptotic bodies were seen in all 4 patients and in 4 of 5 specimens. Mononuclear cells were found in 2 of 4 patients. Small vessel congestion was seen in all patients. Lymphocytic endotheliitis was seen in 1 of 4 patients.
conclusionsThis study shows endotheliitis in amputation specimens of four patients with COVID-19 disease and Rutherford Class 3 acute limb ischemia. The findings in these patients is more likely an infectious angiitis because of COVID-19.
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