ArticleEnvironmental research2021
Perfluorooctanoic acid (PFOA) or perfluorooctane sulfonate (PFOS) and DNA methylation in newborn dried blood spots in the Upstate KIDS cohort.
Article in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Translational toxicoepigenetic Meta-Analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead exposure in mouse and human offspring.Environment international · 2024Pooled it
- Insights into the Neurotoxicology of Traditional and Emerging Per- and Polyfluoroalkyl Substances: Mechanisms and Research Frontiers.Environment & health (Washington, D.C.) · 2026Review
- Maternal antenatal depression and offspring DNA methylation.Journal of affective disorders · 2026Article
- Associations between per- and polyfluoroalkyl substances (PFAS), DNA methylation and gene expression from background exposed Norwegian women (2003-2006).Scientific reports · 2026Article
- Certification of a novel matrix reference material for accurate measurements of PFOS and PFOA in prawn.Analytical and bioanalytical chemistry · 2025Article
- Review
- Mouse metastable epialleles are extremely rare.Nucleic acids research · 2025Article
- Epigenetic Consequences of In Utero PFAS Exposure: Implications for Development and Long-Term Health.International journal of environmental research and public health · 2025Review
- Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood.Frontiers in public health · 2025Article
- Prenatal per- and polyfluoroalkyl substance exposures and DNA methylation among newborns in the Environmental influences on Child Health Outcomes program.Environmental epigenetics · 2025Article
- Article
- Examination of newborn DNA methylation among women with polycystic ovary syndrome/hirsutism.Epigenetics · 2023Article
- Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study.Journal of exposure science & environmental epidemiology · 2023Article
- A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots.Journal of exposure science & environmental epidemiology · 2023Review
- Epigenetic gestational age and the relationship with developmental milestones in early childhood.Human molecular genetics · 2023Article
- Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother-infant Pairs cohort.Clinical epigenetics · 2023Article
- Marks and Mechanisms: Unraveling Potential Health Impacts of PFAS via DNA Methylation.Environmental health perspectives · 2022Article
- Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study.Environmental health perspectives · 2022Article
- Developmental toxicant exposures and sex-specific effects on epigenetic programming and cardiovascular health across generations.Environmental epigenetics · 2022Review
- Conception by fertility treatment and offspring deoxyribonucleic acid methylation.Fertility and sterility · 2021Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are persistent organic pollutants which may alter prenatal development, potentially through epigenetic modifications. Prior studies examining PFOS/PFOA and DNA methylation have relatively few subjects (n < 200) and inconsistent results. We examined relations of PFOA/PFOS with DNA methylation among 597 neonates in the Upstate KIDS cohort study. PFOA/PFOS were quantified in newborn dried blood spots (DBS) using high-performance liquid chromatography/tandem mass spectrometry. DNA methylation was measured using the Infinium MethylationEPIC BeadChip with DNA extracted from DBS. Robust linear regression was used to examine the associations of PFOA/PFOS with DNA methylation at individual CpG sites. Covariates included sample plate, estimated cell type, epigenetically derived ancestry, infant sex and plurality, indicators of maternal socioeconomic status, and prior pregnancy loss. In supplemental analysis, we restricted the analysis to 2242 CpG sites previously identified as Correlated Regions of Systemic Interindividual Variation (CoRSIVs) which include metastable epialleles. At FDR<0.05, PFOA concentration >90th percentile was related to DNA methylation at cg15557840, near SCRT2, SRXN1; PFOS>90th percentile was related to 2 CpG sites in a sex-specific manner (cg19039925 in GVIN1 in boys and cg05754408 in ZNF26 in girls). When analysis was restricted to CoRSIVs, log-scaled, continuous PFOS concentration was related to DNA methylation at cg03278866 within PTBP1. In conclusion, there was limited evidence of an association between high concentrations of PFOA/PFOS and DNA methylation in newborn DBS in the Upstate KIDS cohort. These findings merit replication in populations with a higher median concentration of PFOA/PFOS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.