Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2021
Caries arrest effectiveness of silver diamine fluoride compared to alternative restorative technique: randomized clinical trial.
Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Silver diamine fluoride versus atraumatic restorative treatment for management of childhood caries: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Comparative success of minimally invasive treatments for cavitated caries in primary teeth: a network meta-analysis.BMC oral health · 2025Pooled it
- Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults.The Cochrane database of systematic reviews · 2024Pooled it
- The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and meta-analysis.Frontiers in oral health · 2024Pooled it
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Silver Diamine Fluoride (SDF) Efficacy in Arresting Cavitated Caries Lesions in Primary Molars: A Systematic Review and Metanalysis.International journal of environmental research and public health · 2022Pooled it
- Comparative evaluation of saturated and 10% potassium iodide in reducing silver diamine fluoride staining under RMGIC restorations in primary teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Trial
- Efficacy of 30% silver diamine fluoride compared to atraumatic restorative treatment in arresting dentin caries lesions in preschoolers: a randomized clinical trial.Clinical oral investigations · 2024Trial
- Effect of Silver Diamine Fluoride on Caries Arrest and Prevention: The CariedAway School-Based Randomized Clinical Trial.JAMA network open · 2023Trial
- Clinical decision-making in pulp therapy of primary teeth among Tunisian dental practitioners: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Silver diamine fluoride for non-operative restorative treatment and prevention of dental caries.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026Review
- Effectiveness of silver diamine fluoride in preventing and arresting dental caries in pediatric dentistry.Dental research journal · 2026Review
- Multiscale Design of Dental Restorative Materials: Mechanistic Foundations, Technological Innovations, and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Silver diamine fluoride: the science behind the action - a narrative review.BMC oral health · 2025Review
- Silver diamine fluoride versus sodium fluoride varnish in the treatment of proximal caries in primary molars: A randomized clinical trial.The Saudi dental journal · 2025Article
- Article
- Article
- Knowledge, Practices, and Attitudes Towards Silver Diamine Fluoride Therapy Among Dentists and Students in Southeastern Spain.Dentistry journal · 2025Article
- Arresting Active Carious Lesions Using Minimal Intervention Dentistry among a Group of Preschool Children: A Randomized Controlled Clinical Trial.International journal of clinical pediatric dentistry · 2024Article
- Silver Diamine Fluoride in Pediatric Dentistry: Effectiveness in Preventing and Arresting Dental Caries-A Systematic Review.Children (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis RCT study assessed and compared the effect of a biannual application of 38% silver diamine fluoride (SDF) with alternative restorative technique (ART) on arresting caries in primary dentition.
methodsThe RCT was conducted over a period of 12 months and included 79 healthy children (237 primary teeth), aged 3-8 years, selected from the University Pediatric Dentistry outpatient clinics, with at least one primary asymptomatic tooth with active dentinal occlusal/labial lesions. Children were randomly assigned to SDF application or ART treatment. Visual and tactile examinations were used after 6 and 12 months to assess the activity of the carious lesions using the ICDAS II.
resultsAt 6- and 12-month-evaluation periods, no statistically significant differences in lesions arrest were found between SDF and ART groups (P = 1.000). Considering the frequency of arrested caries between the test groups at 6 and 12 months, no significant differences were observed between anterior and posterior lesions, as well as between the maxillary and mandibular lesions. When comparing the working time for the two treatments, the median time for those treated with SDF was 3.3 min, compared to 14.4 min for ART and was statistically significant (P < 0.0001).
conclusionBoth SDF and ART are, indeed, effective for arresting caries. However, the chair-time management required for SDF is significantly shorter compared to ART. Taking into consideration the present evidence, the best decision regarding disease management and application of SDF or ART is to be made by the dentist and the patient/parent, recognizing individuals' differences and preferences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.