ArticleInternational urology and nephrology2021
The association between platelet indices and cardiovascular events in chronic kidney disease patients without dialysis.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Development and validation of interpretable machine learning models to predict intensive care unit outcomes in patients on hemodialysis: a multicenter study.BMC medical informatics and decision making · 2025Article
- Explainable machine learning algorithm to predict cardiovascular event in patients undergoing peritoneal dialysis.BMC medical informatics and decision making · 2025Article
- The relationship of platelet distribution width with all-cause and cardiovascular mortality in peritoneal dialysis patients.Renal failure · 2024Article
- Association between perioperative platelet distribution width changes and postoperative acute kidney injury in patients with renal insufficiency: a retrospective study.BMC nephrology · 2024Article
- The impact of depression on platelet activation, cardiocerebral vascular events and arteriovenous fistula dysfunction in patients undergoing haemodialysis.Scientific reports · 2024Article
- Article
- Systemic immune inflammation index and all-cause mortality in chronic kidney disease: A prospective cohort study.Immunity, inflammation and disease · 2024Article
- The relationship between platelet distribution width and new-onset cardiovascular disease events in patients with peritoneal dialysis.Renal failure · 2022Article
- Activated Platelets, the Booster of Chronic Kidney Disease and Cardiovascular Complications.Kidney diseases (Basel, Switzerland) · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposePrevious studies have indicated that platelet indices are related to the pathogenesis of cardiovascular diseases (CVD). However, it is unclear which platelet-related indicators are associated with CVD events in patients with chronic kidney disease (CKD) without dialysis.
methodsWe performed a single-center prospective cohort study involved 1391 CKD patients to explore the relationship between platelet indices and CVD events in CKD patients. A nomogram was generated to predict CVD-free survival after 3 and 5 years of follow-up in terms of the fitted Cox regression model. And the time-dependent receiver-operating characteristic (ROC) curves were applied to evaluate the prediction accuracy of platelet indices on CVD events.
resultsDuring a median follow-up of 3.41 years, 211 (15.2%) patients experienced CVD events. Results showed that platelet counts (PLT), plateletcrit (PCT), platelet-large cell ratio (P-LCR), and platelet distribution width (PDW) among 5 platelet indices were significantly lower in advanced CKD stages. Cox regression model showed that PLT, PDW, and PCT were associated with CVD events. However, after multivariable-adjusted, low level of PLT, hazard ratio (HR) 0.994 and 95% confidence interval (95% CI 0.989-1.000, p = 0.04), and PDW, HR 0.936 (95% CI 0.878-0.998, p = 0.044) predicted CVD events. The area under the ROC curve (AUC) of platelet indices assessed by time-dependent ROC curve analysis showed that only PLT and PDW were significant for predicting CVD events for 5 years.
conclusionsWe demonstrated that PLT and PDW among 5 platelet indices were independently associated with CVD events in patients with CKD.
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