Evidence map›Paper›PMID 33387150›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2021

Peroral endoscopic myotomy as treatment for Zenker's diverticulum (Z-POEM): a multi-center international study.

Shaimaa Elkholy, Mohamed El-Sherbiny, Roberto Delano-Alonso, Jose de Jesus Herrera-Esquivel, Carlos Valenzuela-Salazar, Andres Rodriguez-Parra, Ignacio Del Rio-Suarez, Jorge Vargas-Madrigal, Tarik Akar, Süleyman Günay and 9 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Observational
  5. Review
  6. Peroral endoscopic tunneling stricturotomy for diverticulum treatment: novel procedure for pediatric esophageal anastomotic diverticula.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2026
    Article
  7. Article
  8. Myectomy for Giant Zenker's Diverticulum.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Efficacy and Safety of Peroral Endoscopic Myotomy in the Treatment of Zenker's Diverticulum: A Single-Center Experience.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024
    Article
  15. Article
  16. Tunneling-free peroral endoscopic septotomy for Zenker diverticulum.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023
    Article
  17. Evaluation of Esophageal Dysphagia in Elderly Patients.Current gastroenterology reports · 2023
    Review
  18. Article
  19. Novel non-injection non-tunnel technique for peroral endoscopic myotomy of Zenker's diverticulum.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 5 countries.

Shaimaa ElkholyGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Kasr Alainy Street Cairo, Cairo, 11311, Egypt. shuma50082@gmail.com.ORCID 0000-0003-4322-6467
Mohamed El-SherbinyGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Kasr Alainy Street Cairo, Cairo, 11311, Egypt.
Roberto Delano-AlonsoGastroenterology Department, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
Jose de Jesus Herrera-EsquivelGastroenterology Department, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
Carlos Valenzuela-SalazarGastroenterology Department, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
Andres Rodriguez-ParraGastroenterology Department, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
Ignacio Del Rio-SuarezGastroenterology Department, Manuel Gea Gonzalez General Hospital, Mexico City, Mexico.
Jorge Vargas-MadrigalGastroenterology Department, Enrique Baltodano Briceno Hospital, Liberia, Costa Rica.
Tarik AkarGastroenterology Department, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
Süleyman GünayGastroenterology Department, Ataturk Education and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.
Zaher HoumaniGastroenterology Department, Faculty of Medicine, Najdeh Hospital, Lebanese University, Beirut, Lebanon.
Bahri AbayliGastroenterology Department, Seyhan State Hospital, Adana, Turkey.
Mohammad A ElkadyGastroenterology and Hepatology Department, Theodor Bilharz Research Institute, Cairo, Egypt.
Ahmed AlzamzamyGastroenterology and Hepatology Department, Military Medical Academy, Cairo, Egypt.
Mahmoud WahbaGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Kasr Alainy Street Cairo, Cairo, 11311, Egypt.
Ahmad MadkourEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
Reem Ezzat MahdyGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Assuit University, Assuit, Egypt.
Kareem EssamGastroenterology Division, Internal Medicine Department, Faculty of Medicine, Cairo University, Kasr Alainy Street Cairo, Cairo, 11311, Egypt.
Mouen A KhashabDivision of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, USA.
Hospital General Dr. Manuel Gea Gonzalez · MXCairo University · EGAssiut University · EGBülent Ecevit University · TRHelwan University · EGIzmir Kâtip Çelebi University · TRJohns Hopkins Hospital · USLebanese University · LBMilitary Medical Academy · EGSeyhan Devlet HastanesiTheodor Bilharz Research Institute · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeroral endoscopic myotomy for the treatment of Zenker's diverticulum (Z-POEM) is a novel technique that has been described in several recent reports. This method utilizes the third space (submucosal layer) to create a tunnel to facilitate complete visualization of the septum and hence cutting it entirely. Conventional endoscopic septotomy carries the risk of recurrence due to incomplete visualization of the septum. While surgical correction is a risky and lengthy procedure in old comorbid patients with Zenker's diverticulum. The aim of this study is to assess the efficacy and safety of Z-POEM.

methodsThe study enrolled 24 patients diagnosed with Zenker's diverticulum (ZD) who underwent Z-POEM at seven independent endoscopy centers in five different countries.

resultsMean patient age ± standard deviation (SD) was 74.3 ± 11 years. Most of the patients were males (n = 20, 83.3%); four (16.7%) were females. More than 50% of the patients (n = 14, 58.3%) had associated comorbidities. The mean size of the diverticula was 4 cm (range 2-7 cm). The Kothari-Haber Score was used to assess clinical symptoms; values ranged from 6 to 14 (median = 9). We achieved 100% technical success with a median procedure time of 61 min and no adverse events. Median hospital stay was 1 day (range 1-5 days). There is a significant reduction in the Kothari-Haber Score after Z-POEM (P < 0.0001). Technical success was achieved in 100% of the patients. Clinical success was achieved in 23/24 (95.8%) of the patients with a median follow-up of 10 months (range 6-24 months).

conclusionZ-POEM is a safe and effective modality for managing ZD.

Indexed as

Digestive System Surgical ProceduresMyotomyZenker DiverticulumEndoscopyFemaleHumansMaleTreatment OutcomeDysphagiaEndoscopic diverticulectomyPeroral endoscopic myotomy (POEM)Third-space endoscopyZenker’s diverticulum (ZD)

Identifiers

PMID33387150
OpenAlexW3115186644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.