Evidence map›Paper›PMID 33387129›Full record

SynthesisBiochemical genetics2021

Association of C677T (rs1081133) and A1298C (rs1801131) Methylenetetrahydrofolate Reductase Variants with Breast Cancer Susceptibility Among Asians: A Systematic Review and Meta-Analysis.

Maryam Rezaee, Hamed Akbari, Mohammad Amin Momeni-Moghaddam, Fatemeh Moazzen, Sarvenaz Salahi, Reza Jahankhah, Sedigheh Tahmasebi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Biochemical genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Maryam RezaeeDermatology Department, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Hamed AkbariStudent Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Mohammad Amin Momeni-MoghaddamDepartment of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran.
Fatemeh MoazzenDepartment of Hematology, Faculty of Allied Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
Sarvenaz SalahiMinimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
Reza JahankhahDepartment of Radiology, Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sedigheh TahmasebiBreast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. tahmasebikh@gmail.com.ORCID http://orcid.org/0000-0001-5880-2063
Shiraz University of Medical Sciences · IRBushehr University of Medical Sciences · IRGonabad University of Medical Sciences · IRIran University of Medical Sciences · IRKerman University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and meta-analysis were conducted to investigate the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with breast cancer (BC) in Asians. Systematic searches were conducted in PubMed, EMBASE, Web of Science, and Scopus by May 2020. Inter-study heterogeneity was also assessed with a Q test, along with I

Indexed as

Genetic Predisposition to DiseaseMutation, MissenseAmino Acid SubstitutionAsian PeopleBreast NeoplasmsFemaleHumansMethylenetetrahydrofolate Reductase (NADPH2)Neoplasm ProteinsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanNeoplasm ProteinsBreast cancerMethylenetetrahydrofolate reductasePolymorphismSNPVariant

Identifiers

PMID33387129
OpenAlexW3118217539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.