Evidence map›Paper›PMID 33387010›Full record

ArticleJournal of neurology2021

COVID-19 in children with neuromuscular disorders.

Daniel Natera-de Benito, Sergio Aguilera-Albesa, Laura Costa-Comellas, Mar García-Romero, María Concepción Miranda-Herrero, Júlia Rúbies Olives, Óscar García-Campos, Elena Martínez Del Val, Maria Josefa Martinez Garcia, Inmaculada Medina Martínez and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

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  11. How to define and enhance diagnostic and assistance pathways in neuromuscular diseases during the COVID-19 pandemic: the concept of network.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

Daniel Natera-de BenitoDepartment of Pediatric Neurology, Neuromuscular UnitHospital Sant Joan de Déu and Institut de Recerca Sant Joan de Déu Passeig Sant Joan de Déu, 2Esplugues de Llobregat, 08950, Barcelona, Spain. dnatera@sjdhospitalbarcelona.org.ORCID http://orcid.org/0000-0001-7764-2085
Sergio Aguilera-AlbesaPediatric Neurology Unit, Department of Pediatrics, Complejo Hospitalario de Navarra, Navarrabiomed, Pamplona, Spain.
Laura Costa-ComellasPediatric Neuromuscular Disorders Unit, Pediatric Neurology, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
Mar García-RomeroDepartment of Pediatric Neurology, Hospital la Paz, Madrid, Spain.
María Concepción Miranda-HerreroDepartment of Pediatric Neurology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Júlia Rúbies OlivesDepartment of Pediatric Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain.
Óscar García-CamposDepartment of Pediatric Neurology, Hospital General Universitario de Toledo, Toledo, Spain.
Elena Martínez Del ValDepartment of Pediatrics, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Maria Josefa Martinez GarciaPediatric Neurology Unit, Department of Pediatrics, Hospital Virgen de la Arrixaca, Murcia, Spain.
Inmaculada Medina MartínezDepartment of Pediatrics, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Ramón Cancho-CandelaDepartment of Pediatrics, Hospital Universitario Río Hortega, Valladolid, Spain.
Miguel A Fernandez-GarciaNeuromuscular Service, Department of Paediatric Neurology, Evelina Children´s Hospital, Guy´s and St Thomas´Hospital NHS Foundation Trust, London, UK.
Samuel Ignacio Pascual-PascualDepartment of Pediatric Neurology, Hospital la Paz, Madrid, Spain.
David Gómez-AndrésPediatric Neuromuscular Disorders Unit, Pediatric Neurology, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
Andres NascimentoDepartment of Pediatric Neurology, Neuromuscular UnitHospital Sant Joan de Déu and Institut de Recerca Sant Joan de Déu Passeig Sant Joan de Déu, 2Esplugues de Llobregat, 08950, Barcelona, Spain.
Neuromuscular Working Group of Spanish Pediatric Neurology Society
Hospital Universitario Virgen de las Nieves · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitario La Paz · ESVall d'Hebron Institut de Recerca · ESComplejo Hospitalario de Navarra · ESComplejo Hospitalario Universitario de Toledo · ESHospital General Universitario Gregorio Marañón · ESHospital Universitario Fundación Alcorcón · ESHospital Universitario Río Hortega · ESHospital Universitario Son Espases · ESHospital Universitario Virgen de la Arrixaca · ESSt Thomas' Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChildren with neuromuscular disorders have been assumed to be a particularly vulnerable population since the beginning of COVID-19. Although this is a plausible hypothesis, there is no evidence that complications or mortality rates in neuromuscular patients are higher than in the general population. The aim of this study is to describe the clinical characteristics and outcome of COVID-19 in children with neuromuscular disorders.

methodsA registry of children with neuromuscular conditions and laboratory-confirmed-SARS-CoV-2 infection was set up by the Neuromuscular Working Group of the Spanish Pediatric Neurology Society (SENEP). Data to be collected were focused on the characteristics and baseline status of the neuromuscular condition and the course of COVID-19.

resultsSevere complications were not observed in our series of 29 children with neuromuscular disorders infected by SARS-CoV-2. Eighty-nine percent of patients were clinically categorized as asymptomatic or mild cases and 10% as moderate cases. Patients with a relatively more severe course of COVID-19 had SMA type 1 and were between 1 and 3 years.

conclusionsThe course of COVID-19 in children with neuromuscular disorders may not be as severe as expected. The protective role of young age seems to outweigh the risk factors that are common in neuromuscular patients, such as a decreased respiratory capacity or a weak cough. Further studies are needed to know if this finding can be generalized to children with other chronic diseases.

Indexed as

COVID-19Neuromuscular DiseasesChildHumansRisk FactorsSARS-CoV-2Duchenne muscular dystrophyMyastheniaMyopathyNeuropathySARS-CoV-2Spinal muscular atrophy

Identifiers

PMID33387010
PMCPMC7775833
OpenAlexW3116242198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.