Evidence map›Paper›PMID 33386992›Full record

ArticlePflugers Archiv : European journal of physiology2021

Soluble αKlotho downregulates Orai1-mediated store-operated Ca

Ji-Hee Kim, Eun Young Park, Kyu-Hee Hwang, Kyu-Sang Park, Seong Jin Choi, Seung-Kuy Cha

Open access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. PKC regulates αKlotho gene expression in MDCK and NRK-52E cells.Pflugers Archiv : European journal of physiology · 2024
    Article
  2. Article
  3. [Research Progress of Klotho in Lung Neoplasms].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023
    Article
  4. Article
  5. Enhanced CaInternational journal of molecular sciences · 2022
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ji-Hee KimDepartment of Physiology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwondo, 26426, Republic of Korea.
Eun Young ParkDepartment of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Kyu-Hee HwangDepartment of Physiology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwondo, 26426, Republic of Korea.
Kyu-Sang ParkDepartment of Physiology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwondo, 26426, Republic of Korea.
Seong Jin ChoiDepartment of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwondo, 26426, Republic of Korea. choisj@yonsei.ac.kr.
Seung-Kuy ChaDepartment of Physiology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju, Gangwondo, 26426, Republic of Korea. skcha@yonsei.ac.kr.ORCID 0000-0003-3201-7950
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

αKlotho is a type 1 transmembrane anti-aging protein. αKlotho-deficient mice have premature aging phenotypes and an imbalance of ion homeostasis including Ca

Indexed as

Calcium SignalingCalciumCell Line, TumorDown-RegulationHEK293 CellsHumansKlotho ProteinsNeoplasm ProteinsORAI1 ProteinPhosphatidylinositol 3-KinasesStromal Interaction Molecule 1CalciumKlotho ProteinsKL protein, humanNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanPhosphatidylinositol 3-KinasesSTIM1 protein, humanStromal Interaction Molecule 1CRAC channelFGF23SOCESTIM1

Identifiers

PMID33386992
PMCPMC8049930
OpenAlexW3116747959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.