ArticleThoracic cancer2021
Thymic epithelial tumors: Do we know all the prognostic factors?
Article in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Rising Threat: Long-Term Trends in the Incidence and Mortality of Thymic Epithelial Tumor.Cancer medicine · 2025Article
- Narrative review of the prognostic significance of primary tumor size in thymic epithelial tumor.Mediastinum (Hong Kong, China) · 2025Review
- ACTN4 is associated with the malignant potential of thymic epithelial tumors through the β-catenin/Slug pathway.Cancer science · 2024Article
- Usefulness of Three-Dimensional Iodine Mapping Quantified by Dual-Energy CT for Differentiating Thymic Epithelial Tumors.Journal of clinical medicine · 2023Article
- Prognostic factors in patients with thymoma who underwent surgery.World journal of surgical oncology · 2023Article
- Multi-institutional survey of thymic carcinoma patients in Hokushin region.Journal of cancer research and clinical oncology · 2022Article
- The Studies of Prognostic Factors and the Genetic Polymorphism of Methylenetetrahydrofolate Reductase C667T in Thymic Epithelial Tumors.Frontiers in oncology · 2022Article
- Diagnostic and prognostic value of FDG PET-CT in patients with suspected recurrent thymic epithelial tumors.Scientific reports · 2021Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymic epithelial tumors constitute a morphologically and clinically diverse group of rare neoplasm of the anterior mediastinum.
methodsHere, we present an analysis of 188 patients diagnosed with primary thymic tumors between 1995 and 2015. The prognostic value of selected clinical and morphological factors was assessed in relation to overall survival and recurrence-free survival.
resultsThe risk of recurrence increased significantly in thymic carcinoma diagnosis (P = 0.0036), co-occurrence of other diseases, and weight loss (P = 0.0012 and 0.0348, respectively). Multivariate analysis showed that the most important independent risk factor for disease recurrence was clinical stage IV (P = 0.0036). A total of 63 patients (33.5%) died. In the univariate analysis, the following factors were considered as independent prognostic factors for overall survival: clinical stage (P < 0.0001), histological type (P < 0.0001), lymph node involvement (P < 0.001), WHO performance status 2 (P < 0.0001), anemia (Hb <9.5 g/dL; P = 0.0002), leucocytosis (>12.5 G/L; P = 0.0011), LDH level (>185 U/L; P < 0.0001), concomitant diseases (P = 0.0012) and weight loss (P < 0.0001).The strongest independent risk factor for death was stage IV disease (P < 0.001).
conclusionsThe results confirmed a fairly good prognosis for patients with thymic epithelial tumors. Clinical stage was the most important prognostic factor, but, some additional clinical factors may also have prognostic value.
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