ReviewNeuromolecular medicine2021
High-Intensity Functional Training: Molecular Mechanisms and Benefits.
Review in Neuromolecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of functional training on physical fitness and skill-related performance among basketball players: a systematic review.Frontiers in physiology · 2024Pooled it
- Pooled it
- Physical Adaptations to High-Intensity Multimodal Training in Recreationally Active Adults: A Randomised Control Trial.European journal of sport science · 2026Trial
- Divergent effects of high-intensity functional training and moderate-intensity continuous training in adolescents with overweight/obesity: a randomized controlled trial on body composition, physical fitness, and psychological health.Frontiers in physiology · 2026Trial
- Maximizing sprint performance among adolescent sprinters: a controlled evaluation of functional, traditional, and combined training approaches.Frontiers in public health · 2025Trial
- Comparative effects of high-intensity interval training and moderate-intensity continuous training on weight and metabolic health in college students with obesity.Scientific reports · 2024Trial
- Exercising with a robotic exoskeleton can improve memory and gait in people with Parkinson's disease by facilitating progressive exercise intensity.Scientific reports · 2024Trial
- The interplay between bicarbonate kinetics and gastrointestinal upset on ergogenic potential after sodium bicarbonate intake: a randomized double-blind placebo-controlled trial.Scientific reports · 2023Trial
- Effects of Different Recovery Modalities on Delayed Onset Muscle Soreness, Recovery Perceptions, and Performance Following a Bout of High-Intensity Functional Training.International journal of environmental research and public health · 2023Trial
- Krill-Oil-Dependent Increases in HS-Omega-3 Index, Plasma Choline and Antioxidant Capacity in Well-Conditioned Power Training Athletes.Nutrients · 2021Trial
- Review
- Effect of Different Modes of High Intensity Interval Training on Appetite-Related Hormones, Appetite Perception, and Anthropometric Measures in Overweight and Obese Men: A Randomized Controlled Trial.Health science reports · 2026Article
- Agreement Between Reserve Heart Rate, Perceived Exertion and Wint Index During HIIT Using a Low-Cost ANT+ Armband in University Students.Sensors (Basel, Switzerland) · 2026Article
- The Combined Effect of Acute Interval and Cognitive Training on Visual-Spatial Abilities in Women: Preliminary Insights for Health Promotion.International journal of environmental research and public health · 2025Article
- Effects of 8-Week High-Intensity Interval Training Intervention Regulating the SIRT1/PGC1α Pathway on Hippocampal Neuron Injury and Cognitive Impairment in Obese Rats.Current developments in nutrition · 2025Article
- High Intensity Functional Training in Hybrid Competitions: A Scoping Review of Performance Models and Physiological Adaptations.Journal of functional morphology and kinesiology · 2025Review
- Impact of exercise-induced alterations on gut microbiota diversity and composition: comparing effects of different training modalities.Cell regeneration (London, England) · 2025Article
- The effectiveness of a high-intensity interval exercise on cardiometabolic health and quality of life in older adults: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Extracellular Vesicles in Sport Horses: Potential Biomarkers and Modulators of Exercise Adaptation and Therapeutics.International journal of molecular sciences · 2025Review
- A novel approach to cancer rehabilitation: assessing the influence of exercise intervention on postoperative recovery and survival rates.International journal of surgery (London, England) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-intensity interval training (HIIT) and strength exercise are known to improve health markers, such as cardiovascular health, metabolic health, and cognitive function, as well as to reduce all-cause mortality. High-Intensity Functional Training (HIFT) is a training paradigm derived from both HIIT and strength exercise to elicit greater muscle recruitment than repetitive aerobic exercises, thereby improving both cardiovascular fitness and strength parameters. Herein, we provide a focused review of the known molecular mechanisms that underlie the beneficial effects of HIFT on cardiovascular, metabolic, and cognitive functions.
Indexed as
Identifiers
33386577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.