ArticleCerebral cortex (New York, N.Y. : 1991)2021
Dual-Factor Representation of the Environmental Context in the Retrosplenial Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG.CNS neuroscience & therapeutics · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Unique Transcriptomic Cell Types of the Granular Retrosplenial Cortex Are Preserved across Mice and Rats despite Dramatic Changes in Key Marker Genes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles.Nature neuroscience · 2025Article
- Projection-specific circuits of retrosplenial cortex with differential contributions to spatial cognition.Molecular psychiatry · 2025Article
- Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time.Nature neuroscience · 2025Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- The Retrosplenial Cortical Role in Delayed Spatial Alternation.bioRxiv : the preprint server for biology · 2024Article
- Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles.bioRxiv : the preprint server for biology · 2024Article
- Article
- Time Cells in the Retrosplenial Cortex.bioRxiv : the preprint server for biology · 2024Article
- Review
- Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Running speed and REM sleep control two distinct modes of rapid interhemispheric communication.Cell reports · 2022Article
- Article
- The limbic memory circuit and the neural basis of contextual memory.Neurobiology of learning and memory · 2022Article
- Retrosplenial cortex in spatial memory: focus on immediate early genes mapping.Molecular brain · 2021Review
- Article
- Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory.Neurobiology of learning and memory · 2021Article
- Retrosplenial cortex inactivation during retrieval, but not encoding, impairs remotely acquired auditory fear conditioning in male rats.Neurobiology of learning and memory · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The retrosplenial cortex (RSC) is thought to be involved in a variety of spatial and contextual memory processes. However, we do not know how contextual information might be encoded in the RSC or whether the RSC representations may be distinct from context representations seen in other brain regions such as the hippocampus. We recorded RSC neuronal responses while rats explored different environments and discovered 2 kinds of context representations: one involving a novel rate code in which neurons reliably fire at a higher rate in the preferred context regardless of spatial location, and a second involving context-dependent spatial firing patterns similar to those seen in the hippocampus. This suggests that the RSC employs a unique dual-factor representational mechanism to support contextual memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.