Evidence map›Paper›PMID 33386064›Full record

ArticleAIDS research and human retroviruses2021

Antiretroviral Therapy for HIV-Associated Cutaneous Kaposi's Sarcoma: Clinical, HIV-Related, and Sociodemographic Predictors of Outcome.

Owen Ngalamika, Sody Munsaka, Salum J Lidenge, John T West, Charles Wood

Open access · hybridAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Owen NgalamikaDermatology and Venereology Section, Adult Hospital of the University Teaching Hospitals, University of Zambia School of Medicine, Lusaka, Zambia.
Sody MunsakaDepartment of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.
Salum J LidengeOcean Road Cancer Institute, Academic and Research Unit, Dar es Salaam, Tanzania.
John T WestNebraska Center for Virology, Lincoln, Nebraska, USA.
Charles WoodNebraska Center for Virology, Lincoln, Nebraska, USA.
University of Nebraska–Lincoln · USUniversity of Zambia · ZMUniversity Teaching Hospital · ZM

Funding

Zambia AIDS Malignancies Diagnosis and Pathogenesis Program SupplementU54CA221204 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2017 to 2022
$3.8M
KSHV,HIV and the Kaposi's Sarcoma Tumor NicheR01CA228178 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI WEST, JOHN T., WOOD, CHARLES · 2018 to 2024
$2.9M
AIDS Malignancies Training and Research International Program (AMTRIP)D43TW010354 · FIC · UNIVERSITY OF NEBRASKA LINCOLN · PI Chipepo Kankasa, Charles Wood · 2016 to 2026
$2.8M
Biomarkers of Kaposi sarcoma recrudescence in ZambiaK43TW011095 · FIC · UNIVERSITY OF ZAMBIA · PI NGALAMIKA, OWEN · 2018 to 2023
$721k
FIC NIH HHS D43 TW010354FIC NIH HHS K43 TW011095NCI NIH HHS R01 CA228178NCI NIH HHS U54 CA221204
6 · The paper itself

Abstract

Kaposi's sarcoma (KS) is an AIDS-defining malignancy that can improve or worsen with antiretroviral therapy (ART). We aimed at identifying clinical, HIV-related, and sociodemographic factors associated with either progression or nonprogression (regression or stable disease) of ART-treated HIV-associated KS in patients with limited cutaneous disease. We conducted a prospective cohort study of ART-treated HIV-associated KS cases. Clinical, HIV-related, and sociodemographic variables were collected at baseline, and patients were followed up to determine treatment outcomes. Cox regression, linear mixed effects model, and Spearman's rank correlation were used for analysis. Half (50%) of the study participants had KS regression or stable disease, whereas the other half (50%) had disease progression during the treatment and follow-up period. Among the data analyzed, presence of KS nodules at baseline (hazard ratio = 5.47; 95% confidence interval = 1.32-22.65;

Indexed as

HIV InfectionsSarcoma, KaposiCD4 Lymphocyte CountHumansProspective StudiesViral Loadantiretroviral therapyHIVKaposi's sarcomaoutcomespredictors

Identifiers

PMID33386064
PMCPMC8112720
OpenAlexW3115204181

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.