ReviewAutonomic neuroscience : basic & clinical2021
Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view.
Review in Autonomic neuroscience : basic & clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Breathing technique-dependent acute cardiopulmonary responses during squats in healthy females.Physiological reports · 2026Trial
- Refining determinants of associations of visit-to-visit blood pressure variability with cardiovascular risk: results from the Action to Control Cardiovascular Risk in Diabetes Trial.Journal of hypertension · 2021Trial
- Cerebral oxygenation response to postural change using continuous near-infrared spectroscopy (NIRS) and its association with falls in older adults.European geriatric medicine · 2026Article
- A Closed-Loop Cardiovascular Model of the Supine-To-Stand Manoeuvre: Implications for Falls.International journal for numerical methods in biomedical engineering · 2026Article
- Sit-to-stand and stand-to-sit transitions stimulate cardiac autonomic regulation and lead to age-dependent short-term patterns in heart rate.Frontiers in physiology · 2026Article
- Beat-to-Beat Blood Pressure Monitoring and Orthostatic Hypotension-Related Falls in Two Cohorts of Older Adults.Geriatrics (Basel, Switzerland) · 2025Article
- Characterizing Neurocardiovascular Responses to an Active Stand Test in Older Women: A Pilot Study Using Functional Data Analysis.Sensors (Basel, Switzerland) · 2025Article
- Standing transthoracic echocardiography: a feasibility study.Echo research and practice · 2025Article
- The difference in arterial baroreflex sensitivity between the supine and standing positions in healthy subjects.The journal of physiological sciences : JPS · 2025Article
- Article
- Clinical Assessment of the Autonomic Nervous System.Cardiac electrophysiology clinics · 2024Review
- Recent Advances and Future Directions in Syncope Management: A Comprehensive Narrative Review.Journal of clinical medicine · 2024Review
- Article
- A pilot study to assess the origin of the spectral power increases of heart rate variability associated with transient changes in the R-R interval.Physiological reports · 2024Article
- Mechanisms maintaining cerebral perfusion during systemic hypotension are impaired in elderly adults.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Capturing postural blood pressure dynamics with near-infrared spectroscopy-measured cerebral oxygenation.GeroScience · 2023Article
- Objective Hemodynamic Cardiovascular Autonomic Abnormalities in Post-Acute Sequelae of COVID-19.The Canadian journal of cardiology · 2023Article
- Relationship between sarcopenia and orthostatic blood pressure recovery in older falls clinic attendees.European geriatric medicine · 2023Article
- Central command suppresses pressor-evoked bradycardia at the onset of voluntary standing up in conscious cats.Experimental physiology · 2023Article
- Temporal relationships among changes in the RR-interval and the powers of the low- and high-frequency components of heart rate variability in normal subjects.Physiological reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Transient cardiovascular and cerebrovascular responses within the first minute of active standing provide the means to assess autonomic, cardiovascular and cerebrovascular regulation using a real-world everyday stimulus. Traditionally, these responses have been used to detect autonomic dysfunction, and to identify the hemodynamic correlates of patient symptoms and attributable causes of (pre)syncope and falls. This review addresses the physiology of systemic and cerebrovascular adjustment within the first 60 s after active standing. Mechanical factors induced by standing up cause a temporal mismatch between cardiac output and vascular conductance which leads to an initial blood pressure drops with a nadir around 10 s. The arterial baroreflex counteracts these initial blood pressure drops, but needs 2-3 s to be initiated with a maximal effect occurring at 10 s after standing while, in parallel, cerebral autoregulation buffers these changes within 10 s to maintain adequate cerebral perfusion. Interestingly, both the magnitude of the initial drop and these compensatory mechanisms are thought to be quite well-preserved in healthy aging. It is hoped that the present review serves as a reference for future pathophysiological investigations and epidemiological studies. Further experimental research is needed to unravel the causal mechanisms underlying the emergence of symptoms and relationship with aging and adverse outcomes in variants of orthostatic hypotension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.