ArticleNeuroImage2021
Network-level macroscale structural connectivity predicts propagation of transcranial magnetic stimulation.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcranial magnetic stimulation treatment in Alzheimer's disease: a meta-analysis of its efficacy as a function of protocol characteristics and degree of personalization.Journal of neurology · 2022Pooled it
- Boosting hemianopia recovery: the power of interareal cross-frequency brain stimulation.Brain : a journal of neurology · 2025Trial
- Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation.iScience · 2026Article
- Mechanisms of transcranial magnetic brain stimulation.Physiological reviews · 2026Review
- Neurophysiological signatures of Stanford Neuromodulation Therapy in treatment resistant depression.Molecular psychiatry · 2026Article
- Mapping the Disrupted Connectome in Spinocerebellar Ataxia Type 3: A Network-Based Statistics Study Identifying Novel Therapeutic Targets for Neuromodulation.CNS neuroscience & therapeutics · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Pulse waveform and current direction alter network-level TMS-induced functional connectivity: Evidence from TMS-EEG.NeuroImage · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder.Biological psychiatry global open science · 2026Article
- Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease.Science advances · 2025Article
- Modulation of brain oscillations by continuous theta burst stimulation in patients with insomnia.Translational psychiatry · 2025Article
- Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks.Nature communications · 2025Article
- Evoked slow oscillations and dynamic network reorganization after stroke.Brain communications · 2025Article
- The alterations of repetitive transcranial magnetic stimulation on the energy landscape of resting-state networks differ across the human cortex.Human brain mapping · 2024Article
- Insight into motor fatigue mechanisms in natalizumab treated multiple sclerosis patients with wearing off.Scientific reports · 2024Article
- Unraveling the mesoscale organization induced by network-driven processes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring Motor Network Connectivity in State-Dependent Transcranial Magnetic Stimulation: A Proof-of-Concept Study.Biomedicines · 2024Article
- No Object-Location Memory Improvement through Focal Transcranial Direct Current Stimulation over the Right Temporoparietal Cortex.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Information processing in the brain is mediated by structural white matter pathways and is highly dependent on topological brain properties. Here we combined transcranial magnetic stimulation (TMS) with high-density electroencephalography (EEG) and Diffusion Weighted Imaging (DWI), specifically looking at macroscale connectivity to understand whether regional, network-level or whole-brain structural properties are more responsible for stimulus propagation. Neuronavigated TMS pulses were delivered over two individually defined nodes of the default mode (DMN) and dorsal attention (DAN) networks in a group of healthy subjects, with test-retest reliability assessed 1-month apart. TMS-evoked activity was predicted by the modularity and structural integrity of the stimulated network rather than the targeted region(s) or the whole-brain connectivity, suggesting network-level structural connectivity as more relevant than local and global brain properties in shaping TMS signal propagation. The importance of network structural connectome was unveiled only by evoked activity, but not resting-state data. Future clinicals interventions might enhance target engagement by adopting DWI-guided, network-focused TMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.