Evidence map›Paper›PMID 33385525›Full record

ReviewComparative biochemistry and physiology. Part A, Molecular & integrative physiology2021

Phylogeny and ontogeny of the renin-angiotensin system: Current view and perspectives.

Hiroko Nishimura, Maria Luisa S Sequeira-Lopez

Open access · greenAbstract readReview
In one paragraph

Review in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Hiroko NishimuraChild Health Research Center, University of Virginia, Charlottesville, VA, USA; Kidney Research Center, Niigata University Graduate Sch. of Med. & Dent. Sci., Niigata, Japan. Electronic address: nishimura.uthsc@gmail.com.
Maria Luisa S Sequeira-LopezChild Health Research Center, University of Virginia, Charlottesville, VA, USA.
University of Virginia · US

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI Silvia Medrano · 2012 to 2026
$13.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
Fate of the kidney vasculature during partial neonatal ureteral obstructionR01DK116196 · NIDDK · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL148044NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116196
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) evolved early among vertebrates and remains functioning throughout the vertebrate phylogeny and has adapted to various environments. The RAS is crucial for the regulation of blood pressure, fluid-electrolyte balance and tissue homeostasis. The RAS is also expressed during early ontogeny in renal and extra-renal tissues, and exerts unique vascular growth and differentiation functions. In this brief review, we describe advances from molecular-genetic and whole animal approaches and discuss similarities and unique aspects of the RAS in the context of embryonic development and vertebrates' phylogeny.

Indexed as

AnimalsArteriesArteriolesBlood PressureCell DifferentiationChickensEndothelium, VascularHomeostasisHumansKidneyPhylogenyReninRenin-Angiotensin SystemRNA, MessengerWater-Electrolyte BalanceReninRNA, Messenger

Identifiers

PMID33385525
PMCPMC7920990
OpenAlexW3117651326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.